Colorectal Cancer

Mirazul Islam, a graduate student in the lab of Professor Ken Lau, has developed a molecular clock that records the timing of cellular events at a single-cell resolution. Read More

Coffey and Lau plan to uncover the mechanistic underpinnings of supermeres in the tumor microenvironment, look for other immune exclusion biomarkers, and evaluate the efficacy of immunotherapy when immune exclusion proteins are targeted. Read More

Vanderbilt University Medical Center has received a five-year, $5 million grant from the National Cancer Institute to study precancerous lesions and early cancers in the colon, with the goal of developing new ways to prevent colorectal cancer, the nation’s second leading cancer killer. Robert Coffey, MD, Martha Shrubsole, PhD, and Ken… Read More

Researchers at Vanderbilt University Medical Center have discovered a potential new target in the fight against colorectal cancer, the nation’s third most common malignancy and, next to lung cancer, the second leading cancer killer. This month in the journal Gastroenterology, R. Daniel Beauchamp, MD, Anna Means, PhD,… Read More

The bacterium Clostridioides difficile (C. difficile), which causes severe diarrhea and an estimated 400,000 infections annually in the United States, may be a previously unrecognized contributor to colorectal cancer. The findings from human colon cancer specimens, culturing, and mouse models were reported last month by researchers at Johns Hopkins… Read More

by Tom Wilemon A team of Vanderbilt researchers has revealed some of the mechanisms by which polyps develop into colorectal cancer, setting the framework for improved surveillance for the cancer utilizing precision medicine. Their study, published Dec. 14 in Cell, describes findings from a single-cell transcriptomic and imaging atlas… Read More