Heart

  Heart Disease Vanderbilt University School of Medicine Basic Sciences researchers are investigating the heart at its foundations, from the molecular signals that control contraction and rhythm to the genetic and cellular pathways that drive atherosclerosis, inflammation, and heart failure. This bench-level insight fuels the next generation of diagnostics and… Read More

Heart Disease Vanderbilt University School of Medicine Basic Sciences researchers are investigating the heart at its foundations, from the molecular signals that control contraction and rhythm to the genetic and cellular pathways that drive atherosclerosis, inflammation, and heart failure. This bench-level insight fuels the next generation of diagnostics and therapies,… Read More

Vanderbilt and Northwestern University researchers characterized a group of KCNQ1 variants probe their role in a common heart disorder called LQTS. They found that there are five classes of mutations that act through independent mechanisms, suggesting that a more tailored/personalized treatment approach could be beneficial for LQTS patients. Read More

Research led by Dylan Burnette, associate professor of cell and developmental biology, and first-author Abigail Neininger, a graduate student in the Burnette lab, identified the Hippo pathway as a key regulator of heart muscle cell division, which has large translational implications for treatments after a heart attack. Their article was… Read More

Professor David Merryman explains how his team targeted the serotonin 2B receptor in animal models to preserve cardiac function six weeks after a heart attack. Researchers at Vanderbilt University in the US report that they have identified a protein receptor in specialised heart cells that, when removed, preserves cardiac function… Read More