Tumor-associated Macrophages

The study reported in the journal Nature provides a mechanistic explanation for the “obesity paradox” — that obesity can contribute to cancer progression but also improve response to immunotherapy. Read More

Researchers in the lab of Vivian Weiss, assistant professor of pathology, microbiology, and immunology, recently published a review article in Cancer Research that describes the role of the Wnt pathway in TAMs and tumor biology. Read More

The growth of epithelial ovarian cancer, one of the most lethal malignancies, is associated with the presence of tumor-associated macrophages (TAMs), white blood cells that can block the anti-cancer activity of the immune system and immunotherapy. Fortunately, TAMs can be “repolarized,” converted from immunosuppressive tumor-promoters to inflammatory tumor-fighters. Now,… Read More