Kathleen L. Gould, Ph.D.
Louise B. McGavock Chair, Professor, Department of Cell & Developmental Biology
AAAS Fellow - 2011
- : kathy.gould@vanderbilt.edu
- : (615) 343-9502
- :
B2309 Medical Center North
Research Description
The Gould laboratory conducts foundational research on the molecular basis of cell division, a highly conserved process central to development and tissue maintenance. Eukaryotic cells accomplish cell division with exquisite spatial and temporal control. A key event during cell division is the formation of an actin- and myosin-based cytokinetic ring that constricts to physically separate two new daughter cells. Our lab is fascinated by the question of how the cytokinetic ring is assembled and organized on the plasma membrane. We are also interested in how the assembly and constriction of the cytokinetic ring is coordinated with chromosome segregation to ensure genomic integrity. We have made fundamental, pioneering discoveries in the mechanisms that control cell division using a multi-disciplinary approach that includes super-resolution microscopy, mass spectrometry-based proteomics, genetics, structural biology, biochemisty, and biochemical reconstitution.
Postdoctoral Positions Available
Yes, please see lab website.
Selected Publications
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McDonald NA, Lind AL, Smith SE, Li R, Gould KL. Nanoscale architecture of the Schizosaccharomyces pombe contractile ring. ELife. 2017 Sep 15;6. e28865.
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Snider CE, Willet AH, Chen JS, Arpağ G, Zanic M, Gould KL. Phosphoinositide-mediated ring anchoring resists perpendicular forces to promote medial cytokinesis. The Journal of Cell Biology. 2017 Aug 7;216(10). 3041-3050.
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McDonald NA, Takizawa Y, Feoktistova A, Xu P, Ohi MD, Vander Kooi CW, Gould KL. The Tubulation Activity of a Fission Yeast F-BAR Protein Is Dispensable for Its Function in Cytokinesis. Cell Reports. 2016 Jan 26;14(3). 534-46.
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McDonald NA. Vander Kooi CW, Ohi MD, Gould KL. Oligomerization but Not Membrane Bending Underlies the Function of Certain F-BAR Proteins in Cell Motility and Cytokinesis Developmental Cell. 2015 Dec 21;35(6). 725-736.
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Bohnert KA, Grzegorzewska AP, Willet AH, Vander Kooi CW, Kovar DR, Gould KL. SIN-dependent phosphoinhibition of formin multimerization controls fission yeast cytokinesis. Genes & Development. 2013 Oct 1;27(19). 2164-77.