Author
Ken Lau Pioneer of Discovery
Oct. 10, 2013—
CK1 is required for a mitotic checkpoint that delays cytokinesis
Oct. 7, 2013—CK1 is required for a mitotic checkpoint that delays cytokinesis Alyssa E. Johnson, Jun-Song Chen, Kathleen L. Gould Highlights •Dma1’s FHA domain binds to a pTXXpS phosphomotif on Sid4 •CK1 is required for Dma1-dependent Sid4 ubiquitination •CK1 phosphorylation of Sid4 is required for the Dma1-dependent mitotic checkpoint •CK1 concentrates at SPBs and phosphoprimes Sid4 for...
An oligomeric switch that modulates cytokinetic formin function
Oct. 1, 2013—SIN-dependent phosphoinhibition of formin multimerization controls fission yeast cytokinesis K. Adam Bohnert1, Agnieszka P. Grzegorzewska2,3,6, Alaina H. Willet1, Craig W. Vander Kooi4,5, David R. Kovar2,3 and Kathleen L. Gould1,7 Abstract Many eukaryotes accomplish cell division by building and constricting a medial actomyosin-based cytokinetic ring (CR). In Schizosaccharomyces pombe, a Hippo-related signaling pathway termed the septation...
Generalized ideal observer model for decoding sensory neural responses
Sep. 19, 2013—A Generalized ideal observer model for decoding sensory neural responses Gopathy Purushothaman and Vivien A. Casagrande Front. Psychol., 19 September 2013 | doi: 10.3389/fpsyg.2013.00617 Abstract We show that many ideal observer models used to decode neural activity can be generalized to a conceptually and analytically simple form. This enables us to study the statistical properties...
Post-doc Publication: CRISPR/Cas9 method in zebrafish
Aug. 14, 2013—A simple and robust method for targeted mutagenesis in zebrafish has long been sought. Previous methods generate monoallelic mutations in the germ line of F0 animals, usually delaying homozygosity for the mutation to the F2 generation. Generation of robust biallelic mutations in the F0 would allow for phenotypic analysis directly in injected animals. Recently the...
Faculty Appointment: Jason MacGurn, Ph.D.
Jul. 8, 2013—I am very pleased to announce the appointment of Jason MacGurn, Ph.D., to the rank of Assistant Professor of Cell and Developmental Biology on the tenure track, effective August 1, 2013. Jason is currently a Post Doctoral Fellow in Scott Emr’s Lab at Cornell University Weill Institute for Cell and Molecular Biology. He was jointly...
Lab Publication: Insights into the mitotic phosphoproteome
Jun. 3, 2013—Mol Cell Proteomics. 2013 May;12(5):1074-86. doi: 10.1074/mcp.M112.025924. Epub 2013 Jan 7. Comprehensive proteomics analysis reveals new substrates and regulators of the fission yeast clp1/cdc14 phosphatase. Chen JS, Broadus MR, McLean JR, Feoktistova A, Ren L, Gould KL. ‡Howard Hughes Medical Institute and Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, 1161...
Publication: Scribble implicated in control of vesicle traffic
Apr. 4, 2013—The Scribble polarity protein stabilizes E-cadherin/p120-catenin binding and blocks retrieval of E-cadherin to the Golgi. Lohia M, Qin Y, Macara IG. Source Department of Microbiology, Ctr for Cell Signaling, University of Virginia School of Medicine, Charlottesville, VA, USA. Abstract Several polarity proteins, including Scribble (Scrb) have been implicated in control of vesicle traffic, and in...
Student Publication: Asunder promotes dynein recruitment
Apr. 3, 2013—Jodoin JN, Shboul M, Sitaram P, Zein-Sabatto H, Reversade B, Lee E, Lee LA. Department of Cell and Developmental Biology, Vanderbilt University Medical Center, Nashville, TN 37232-8240, USA. Abstract Recruitment of dynein motors to the nuclear surface is an essential step for nucleus-centrosome coupling in prophase. In cultured human cells, this dynein pool is anchored...
Faculty Appointment: Ken Lau, Ph.D.
Mar. 21, 2013—Cell & Developmental Biology welcomes new faculty member Ken Lau, Ph.D. Dr. Ken Lau comes to Vanderbilt after completing his post postdoctorate training in the laboratory of Kenvi Hargis, Ph.D. In the Molecular Pathology Unit at the Massachusetts General Hospital and Harvard Medical School. Dr. Lau was chosen to join the Department of Cell and...