Author
Tyska Lab demonstrate enterocyte microvilli-derived vesicles a novel form of defense
Mar. 12, 2012—Info: Enterocyte Microvillus-Derived Vesicles Detoxify Bacterial Products and Regulate Epithelial-Microbial Interactions David A. Shifrin, Jr., Russell E. McConnell, Rajalakshmi Nambiar, James N. Higginbotham, Robert J. Coffey, and Matthew J. Tyska Current Biology; April 10, 2012 Abstract: The continuous monolayer of intestinal epithelial cells (IECs) lining the gut lumen functions as the site of nutrient absorption...
Kaverina Lab centrosomal versus Golgi-derived microtubules
Mar. 12, 2012—Concerted effort of centrosomal and Golgi-derived microtubules is required for proper Golgi complex assembly but not for maintenance Abstract Assembly of an integral Golgi complex is driven by microtubule (MT)-dependent transport. Conversely, the Golgi itself functions as an unconventional MT-organizing center (MTOC). This raises the question of whether Golgi assembly requires centrosomal MTs or can...
A zebrafish model of lethal congenital contracture syndrome
Mar. 12, 2012—In humans, GLE1 is mutated in lethal congenital contracture syndrome 1 (LCCS1) leading to prenatal death of all affected fetuses. Although the molecular roles of Gle1 in nuclear mRNA export and translation have been documented, no animal models for this disease have been reported. To elucidate the function of Gle1 in vertebrate development, we used...
Myosin-1a membrane binding in microvilli
Feb. 29, 2012—One of the most abundant components of the enterocyte brush border is the actin-based monomeric motor, myosin-1a (Myo1a). Within brush border microvilli, Myo1a carries out a number of critical functions at the interface between membrane and actin cytoskeleton. Proper physiological function of Myo1a depends on its ability to bind to microvillar membrane, an interaction mediated...
Kathy Gould elected as an AAAS Fellow
Feb. 8, 2012—"In November 2011, the AAAS Council elected 539 members as Fellows of AAAS. These individuals will be recognized for their contributions to science and technology at the Fellows Forum to be held on 18 February 2012 during the AAAS Annual Meeting in Vancouver, Canada. The new Fellows will receive a certificate and a blue and...
A new Cdk1 substrate Nsk1 regulates kinetochore
Dec. 8, 2011—Jun-Song Chen1,2, Lucy X. Lu1,2, Melanie D. Ohi2, Kevin M. Creamer3,4, Chauca English2, Janet F. Partridge4, Ryoma Ohi2, and Kathleen L. Gould1,2 1 Howard Hughes Medical Institute & 2 Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN 37212 3 Integrated Program in Biomedical Sciences, University of Tennessee Health Science Center,...
GABAergic synapses in C. elegans
Dec. 7, 2011—Author contributions: S.C.P., J.D.W., J.E.R., and D.M.M. designed research; S.C.P., J.D.W., and J.E.R. performed research; M.S. and W.W.W. contributed unpublished reagents/analytic tools; S.C.P., J.D.W., J.E.R., and D.M.M. analyzed data; S.C.P. and D.M.M. wrote the paper. Abstract Although transcription factors are known to regulate synaptic plasticity, downstream genes that contribute to neural circuit remodeling are largely...
Diabetes Day
Nov. 28, 2011—Jennifer Plank, a current student in Cell and Developmental Biology, received the award in the graduate student category. Working with Patricia Labosky, Ph.D., Jennifer studies regulators of pancreatic beta cell mass expansion. She has identified important roles for the neural crest and for the transcription factor Foxd3 in the beta cell. The findings from both...
Susan Wente named by the ASCB’s Women in Cell Biology (WICB)
Oct. 19, 2011—Susan Wente, Associate Vice Chancellor for Research, Senior Associate Dean for Biomedical Sciences, and Professor, Cell and Developmental Biology, Vanderbilt University School of Medicine, was named by the ASCB’s Women in Cell Biology (WICB) Committee to receive the 2011 WICB Senior Award. Wente is a world-recognized leader and has made seminal advances in three key...
Loss of Foxd3 results in decreased beta cell proliferation and glucose intolerance during pregnancy
Oct. 19, 2011—Jennifer L. Plank, Audrey Y. Frist, Alison W. LeGrone, Mark A. Magnuson and Patricia A. Labosky – Author Affiliations Department of Cell and Developmental Biology (J.L.P., A.Y.F., A.W.L., M.A.M., P.A.L.), Center for Stem Cell Biology (J.L.P., A.Y.F., A.W.L., M.A.M., P.A.L.), Program in Developmental Biology (J.L.P., A.Y.F., A.W.L., M.A.M., P.A.L.), Department of Molecular Physiology and Biophysics...