Author
asymmetry for cytokinesis
May. 14, 2012—The fission yeast septation initiation network (SIN) kinase, Sid2, is required for SIN asymmetry and regulates the SIN scaffold, Cdc11 Anna Feoktistovaa, Jennifer Morrell-Falveya, Jun-Song Chena, N. Sadananda Singh, Mohan K. Balasubramanianb,c, and Kathleen L. Goulda,1 + Affiliations aHoward Hughes Medical Institute and Department of Cell and Developmental Biology, Vanderbilt University, Nashville, TN 37212 bTemasek...
Identification of XIAP as a critical regulator of Wnt signaling
Mar. 21, 2012—beta-catenin accumulates in the nucleus and binds to the transcription factor, TCF/Lef, to activate Wnt target gene transcription. In order for beta-catenin to bind TCF/Lef, however, the transcriptional corepressor Groucho (Gro)/TLE, which is bound to TCF/Lef, must be displaced. Work by Hanson et al. shows that X-linked Inhibitor of Apoptosis (XIAP), an E3 ubiquitin ligase,...
Developmental Biology Vol363-issue2
Mar. 19, 2012—Enteric nervous system specific deletion of Foxd3 disrupts glial cell differentiation and activates compensatory enteric progenitors Abstract The enteric nervous system (ENS) arises from the coordinated migration, expansion and differentiation of vagal and sacral neural crest progenitor cells. During development, vagal neural crest cells enter the foregut and migrate in a rostro-to-caudal direction, colonizing the...
Tyska Lab demonstrate enterocyte microvilli-derived vesicles a novel form of defense
Mar. 12, 2012—Info: Enterocyte Microvillus-Derived Vesicles Detoxify Bacterial Products and Regulate Epithelial-Microbial Interactions David A. Shifrin, Jr., Russell E. McConnell, Rajalakshmi Nambiar, James N. Higginbotham, Robert J. Coffey, and Matthew J. Tyska Current Biology; April 10, 2012 Abstract: The continuous monolayer of intestinal epithelial cells (IECs) lining the gut lumen functions as the site of nutrient absorption...
Kaverina Lab centrosomal versus Golgi-derived microtubules
Mar. 12, 2012—Concerted effort of centrosomal and Golgi-derived microtubules is required for proper Golgi complex assembly but not for maintenance Abstract Assembly of an integral Golgi complex is driven by microtubule (MT)-dependent transport. Conversely, the Golgi itself functions as an unconventional MT-organizing center (MTOC). This raises the question of whether Golgi assembly requires centrosomal MTs or can...
A zebrafish model of lethal congenital contracture syndrome
Mar. 12, 2012—In humans, GLE1 is mutated in lethal congenital contracture syndrome 1 (LCCS1) leading to prenatal death of all affected fetuses. Although the molecular roles of Gle1 in nuclear mRNA export and translation have been documented, no animal models for this disease have been reported. To elucidate the function of Gle1 in vertebrate development, we used...
Myosin-1a membrane binding in microvilli
Feb. 29, 2012—One of the most abundant components of the enterocyte brush border is the actin-based monomeric motor, myosin-1a (Myo1a). Within brush border microvilli, Myo1a carries out a number of critical functions at the interface between membrane and actin cytoskeleton. Proper physiological function of Myo1a depends on its ability to bind to microvillar membrane, an interaction mediated...
Kathy Gould elected as an AAAS Fellow
Feb. 8, 2012—"In November 2011, the AAAS Council elected 539 members as Fellows of AAAS. These individuals will be recognized for their contributions to science and technology at the Fellows Forum to be held on 18 February 2012 during the AAAS Annual Meeting in Vancouver, Canada. The new Fellows will receive a certificate and a blue and...
A new Cdk1 substrate Nsk1 regulates kinetochore
Dec. 8, 2011—Jun-Song Chen1,2, Lucy X. Lu1,2, Melanie D. Ohi2, Kevin M. Creamer3,4, Chauca English2, Janet F. Partridge4, Ryoma Ohi2, and Kathleen L. Gould1,2 1 Howard Hughes Medical Institute & 2 Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN 37212 3 Integrated Program in Biomedical Sciences, University of Tennessee Health Science Center,...
GABAergic synapses in C. elegans
Dec. 7, 2011—Author contributions: S.C.P., J.D.W., J.E.R., and D.M.M. designed research; S.C.P., J.D.W., and J.E.R. performed research; M.S. and W.W.W. contributed unpublished reagents/analytic tools; S.C.P., J.D.W., J.E.R., and D.M.M. analyzed data; S.C.P. and D.M.M. wrote the paper. Abstract Although transcription factors are known to regulate synaptic plasticity, downstream genes that contribute to neural circuit remodeling are largely...