Author
Defects in hepatic Notch signaling
Feb. 11, 2011—Defects in hepatic Notch signaling result in disruption of the communicating intrahepatic bile duct network in mice. Sparks EE, Perrien DS, Huppert KA, Peterson TE, Huppert SS. Department of Cell and Developmental Biology and Center for Stem Cell Biology, Vanderbilt University Medical Center, Nashville, TN 37232, USA. Abstract Abnormal Notch signaling in humans results in...
Foxd3 and Pax3 are important early regulators
Jan. 12, 2011—Cardiac neural crest development requires genetic interaction between the transcription factors Foxd3 and Pax3 Abstract The transcription factors Foxd3 and Pax3 are important early regulators of neural crest (NC) progenitor cell properties. Homozygous mutations of Pax3 or a homozygous NC-specific deletion of Foxd3 cause marked defects in most NC derivatives, but neither loss of both...
Labosky named to direct Office of Postdoctoral Affairs
Jan. 12, 2011—Labosky named to direct Office of Postdoctoral Affairs BY: BILL SNYDER 1/06/2011 – Patricia Labosky, Ph.D., associate professor of Cell & Developmental Biology and of Pharmacology, has been named director of the Office of Postdoctoral Affairs at Vanderbilt University Medical Center. Patricia Labosky, Ph.D. Labosky succeeds Ann Richmond, Ph.D., professor and vice chair of Cancer Biology,...
Cdc14B phosphatase contributes to ciliogenesis in zebrafish
Jan. 12, 2011—Cdc14B phosphatase contributes to ciliogenesis in zebrafish Development. 2011 Jan;138(2):291-302. Clément A, Solnica-Krezel L, Gould KL. Howard Hughes Medical Institute and Department of Cell and Developmental Biology, Vanderbilt University School of Medicine Abstract Progression through the cell cycle relies on oscillation of cyclin-dependent kinase (Cdk) activity. One mechanism for downregulating Cdk signaling is to activate...
Proteoglycan-rich extracellular matrix regulates left-right asymmetry in Xenopus
Jan. 12, 2011—Rapid differential transport of Nodal and Lefty on sulfated proteoglycan-rich extracellular matrix regulates left-right asymmetry in Xenopus Lindsay Marjoram and Christopher Wright Department of Cell and Developmental Biology, Program in Developmental Biology, Vanderbilt University Medical School, Nashville, TN 37232, USA. Author for correspondence (chris.wright@vanderbilt.edu) Summary The spatiotemporally dynamic distribution of instructive ligands within embryonic tissue,...
Gαo represses insulin secretion by reducing vesicular docking in pancreatic beta-cells
Nov. 9, 2010—Gαo represses insulin secretion by reducing vesicular docking in pancreatic beta-cells. Zhao A, Ohara-Imaizumi M, Brissova M, Benninger RK, Xu Y, Hao Y, Abramowitz J, Boulay G, Powers AC, Piston D, Jiang M, Nagamatsu S, Birnbaumer L, Gu G. Department of Cell and Developmental Biology, Vanderbilt University Medical Center, Nashville,Tennessee, USA. Abstract OBJECTIVE: Pertussis toxin...
Small-molecule inhibition of Wnt signaling through activation of casein kinase
Nov. 8, 2010—Small-molecule inhibition of Wnt signaling through activation of casein kinase 1α Curtis A Thorne, Alison J Hanson, Judsen Schneider, Emilios Tahinci, Darren Orton, Christopher S Cselenyi, Kristin K Jernigan, Kelly C Meyers, Brian I Hang, Alex G Waterson, Kwangho Kim, Bruce Melancon, Victor P Ghidu, Gary A Sulikowski, Bonnie LaFleur, Adrian Salic, Laura A...
Selective distribution of deubiquitinating enzymes
Oct. 4, 2010—A Global Census of Fission Yeast Deubiquitinating Enzyme Localization and Interaction Networks Reveals Distinct Compartmentalization Profiles and Overlapping Functions in Endocytosis and Polarity Ilektra Kouranti1,2, Janel R. McLean1,2, Anna Feoktistova1,2, Ping Liang1,2, Alyssa E. Johnson1,2, Rachel H. Roberts-Galbraith1,2, Kathleen L. Gould1,2* 1 Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, Tennessee,...
F-BAR protein regulation
Oct. 4, 2010—Dephosphorylation of F-BAR protein Cdc15 modulates its conformation and stimulates its scaffolding activity at the cell division site. Roberts-Galbraith RH, Ohi MD, Ballif BA, Chen JS, McLeod I, McDonald WH, Gygi SP, Yates JR 3rd, Gould KL. Howard Hughes Medical Institute and Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN...
A nematode model of nociceptor morphogenesis
Sep. 21, 2010—Time-lapse imaging and cell-specific expression profiling reveal dynamic branching and molecular determinants of a multi-dendritic nociceptor in C. elegans. Smith CJ, Watson JD, Spencer WC, O'Brien T, Cha B, Albeg A, Treinin M, Miller DM 3rd. Department of Cell and Developmental Biology, Vanderbilt University, Nashville, TN 37232-8240, USA. Abstract Nociceptive neurons innervate the skin with...