Author
Chemicals turn human embryonic stem cells towards beta cells
Apr. 7, 2009—nature chemical biology 5, 195 – 196 (2009) doi:10.1038/nchembio0409-195 Yu-Ping Yang1 & Chris Wright1 Yu-Ping Yang and Chris Wright are in the Department of Cell and Developmental Biology and the Vanderbilt University Program in Developmental Biology, Vanderbilt University School of Medicine, Nashville, Tennessee, USA. e-mail: chris.wright@vanderbilt.edu Abstract Small-molecule library screening identifies simple imitators of the cellular...
Defining elements in contractile ring assembly
Mar. 27, 2009—Vanderbilt Reporter, Lords of the contractile ring Cell division requires the formation of a contractile ring. While many protein components of this ring are known, how they interact with each other and with the plasma membrane remains unclear. Rachel Roberts-Galbraith, Kathy Gould, Ph.D., and colleagues are studying these ring proteins in yeast. One such protein,...
Membrane Curvature’s Pore Relation
Mar. 20, 2009—ER membrane–bending proteins are necessary for de novo nuclear pore formation T. Renee Dawson1, Michelle D. Lazarus1, Martin W. Hetzer2, and Susan R. Wente1 1 Department of Cell and Developmental Biology, Vanderbilt University Medical Center, Nashville, TN 37232 2 Molecular and Cell Biology Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037 Correspondence to...
Cells cycle with no poles
Feb. 18, 2009—Cells cycle with no poles- no poles encodes a predicted E3 ubiquitin ligase required for early embryonic development of Drosophila Julie A. Merkle1, Jamie L. Rickmyre1, Aprajita Garg2, Erin B. Loggins1, Jeanne N. Jodoin1, Ethan Lee1, Louisa P. Wu2 and Laura A. Lee1,* 1 Department of Cell and Developmental Biology, Vanderbilt University Medical Center, U-4200...
Diet and insulin in a stem cell niche Hormonal signaling in the fruit fly
Jan. 23, 2009—Diet and insulin in a stem cell niche Hormonal signaling in the fruit fly ovary keeps the niche young. Insulin reverses the effects of aging and poor diet, at least on cells within the ovaries of fruit flies. Biologists Daniela Drummond-Barbosa and Hwei-Jan Hsu of Vanderbilt University in Nashville, Tennessee, found that boosting levels of...
Understanding the molecular mechanisms of stem cell maintenance
Dec. 30, 2008—Labosky lab establishes a conserved role for the stem cell gene Foxd3 in maintenance of multipotent neural crest progenitor cells in the mouse embryo. Lu Teng1,*,, Nathan A. Mundell2,4,, Audrey Y. Frist3,4, Qiaohong Wang1 and Patricia A. Labosky1,2,3,4, 1 Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104-6058, USA....
Vice Chancellor for Research
Nov. 21, 2008—Three Vanderbilt University School of Medicine faculty members are taking on new leadership roles. Susan Wente, Ph.D., has been named assistant vice chancellor for Research.
Young Innovator Award
Oct. 6, 2008—NIH Director’s New Innovator Award recipient As part of NIH's commitment to increasing opportunities for new scientists, it has created the NIH Director's New Innovator Award to support exceptionally creative new investigators who propose highly innovative projects that have the potential for unusually high impact. Melanie Ohi recently received the highly competitive National Institutes of...
The Clp1-Cdc14 phosphatase contributes to the robustness of cytokinesis by association with anillin-related Mid1
Oct. 6, 2008—The Clp1/Cdc14 phosphatase contributes to the robustness of cytokinesis by association with anillin-related Mid Cdc14 phosphatases antagonize cyclin-dependent kinase–directed phosphorylation events and are involved in several facets of cell cycle control. We investigate the role of the fission yeast Cdc14 homologue Clp1/Flp1 in cytokinesis. We find that Clp1/Flp1 is tethered at the contractile ring (CR)...