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The Purkinje neuron acts as a central regulator of spatially and functionally distinct cerebellar precursors Jonathan T. Fleming, Wenjuan He, Chuanming Hao, Tatiana Ketova, Fong C. Pan, Christopher C.V. Wright, Ying Litingtung, Chin Chiang Highlights •Purkinje neurons signal bidirectionally to expand functionally divergent cell types •Nascent white matter… Read More

The Purkinje Neuron Acts as a Central Regulator of Spatially and Functionally Distinct Cerebellar Precursors Jonathan T. Fleming, Wenjuan He, Chuanming Hao, Tatiana Ketova, Fong C. Pan, Christopher C.V. Wright, Ying Litingtung, Chin Chiangemail DOI: http://dx.doi.org/10.1016/j.devcel.2013.10.008     Highlights   •Purkinje… Read More

Targeting the Wnt Pathway in Synovial Sarcoma Models Whitney Barham1, Andrea L. Frump5, Taylor P. Sherrill3, Christina B. Garcia7, Kenyi Saito-Diaz5, Michael N. VanSaun2, Barbara Fingleton1, Linda Gleaves3, Darren Orton6, Mario R. Capecchi8, Timothy S. Blackwell3, Ethan Lee4,5, Fiona Yull1 and Josiane E. Eid1 Abstract Synovial sarcoma… Read More

Summary The conserved multifunctional protein Gle1 regulates gene expression at multiple steps: nuclear mRNA export, translation initiation, and translation termination. A GLE1 mutation (FinMajor) is causally linked to human lethal congenital contracture syndrome-1 (LCCS1); however, the resulting perturbations on Gle1 molecular function were unknown. FinMajor results in a… Read More

Retinotopic maps in the pulvinar of bush baby (otolemur garnettii) K. Li1, J. Patel2, G. Purushothaman2, R.T. Marion3 andV.A. Casagrande1,2,3,4,* Article first published online: 23 AUG 2013 DOI: 10.1002/cne.23358 Abstract Despite its anatomical prominence, the function of the primate pulvinar is poorly understood. A few electrophysiological studies in… Read More

CK1 is required for a mitotic checkpoint that delays cytokinesis Alyssa E. Johnson, Jun-Song Chen, Kathleen L. Gould Highlights •Dma1’s FHA domain binds to a pTXXpS phosphomotif on Sid4 •CK1 is required for Dma1-dependent Sid4 ubiquitination •CK1 phosphorylation of Sid4 is required for the Dma1-dependent mitotic checkpoint… Read More

SIN-dependent phosphoinhibition of formin multimerization controls fission yeast cytokinesis K. Adam Bohnert1, Agnieszka P. Grzegorzewska2,3,6, Alaina H. Willet1, Craig W. Vander Kooi4,5, David R. Kovar2,3 and Kathleen L. Gould1,7 Abstract Many eukaryotes accomplish cell division by building and constricting a medial actomyosin-based cytokinetic ring (CR). In Schizosaccharomyces pombe,… Read More

A Generalized ideal observer model for decoding sensory neural responses Gopathy Purushothaman and Vivien A. Casagrande  Front. Psychol., 19 September 2013 | doi: 10.3389/fpsyg.2013.00617 Abstract We show that many ideal observer models used to decode neural activity can be generalized to a conceptually and analytically simple form. Read More

A simple and robust method for targeted mutagenesis in zebrafish has long been sought. Previous methods generate monoallelic mutations in the germ line of F0 animals, usually delaying homozygosity for the mutation to the F2 generation. Generation of robust biallelic mutations in the F0 would allow for phenotypic analysis directly… Read More