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Apical polarization and lumenogenesis: The apicosome sheds new light.


AUTHORS

Romero-Morales AI , Ortolano NA , Gama V , . The Journal of cell biology. 2017 12 4; 216(12). 3891-3893

ABSTRACT

Establishment of apico-basal polarity is critical for the lumenal epiblast-like morphogenesis of human pluripotent stem cells (hPSCs). In this issue, Taniguchi et al. (2017. https://doi.org/10.1083.jcb201704085) describe a structure called the apicosome, generated in single hPSCs, that allows them to self-organize and form the lumenal epiblast-like stage.



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