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Molecular Physiology & Biophysics

Cerebrospinal fluid (CSF) biomarkers of iron status are associated with CSF viral load, antiretroviral therapy, and demographic factors in HIV-infected adults.

AUTHORS

Patton SM , Wang Q , Hulgan T , Connor JR , Jia P , Zhao Z , Letendre SL , Ellis RJ , Bush WS , Samuels DC , Franklin DR , Kaur H , Iudicello J , Grant I , Kallianpur AR , . Fluids and barriers of the CNS. 2017 4 21; 14(1). 11

ABSTRACT

HIV-associated neurocognitive disorder (HAND) remains common, despite antiretroviral therapy (ART). HIV dysregulates iron metabolism, but cerebrospinal fluid (CSF) levels of iron and iron-transport proteins in HIV-infected (HIV+) persons are largely unknown. The objectives of this study were to characterize CSF iron-related biomarkers in HIV+ adults and explore their relationships to known predictors of HAND.

HIV-associated neurocognitive disorder (HAND) remains common, despite antiretroviral therapy (ART). HIV dysregulates iron metabolism, but cerebrospinal fluid (CSF) levels of iron and iron-transport proteins in HIV-infected (HIV+) persons are largely unknown. The objectives of this study were to characterize CSF iron-related biomarkers in HIV+ adults and explore their relationships to known predictors of HAND.

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