Skip to main content

Molecular Physiology & Biophysics

A computational method for genotype calling in family-based sequencing data.

AUTHORS

Chang LC , Li B , Fang Z , Vrieze S , McGue M , Iacono WG , Tseng GC , Chen W , . BMC bioinformatics. 2016 1 16; 17(). 37

ABSTRACT

As sequencing technologies can help researchers detect common and rare variants across the human genome in many individuals, it is known that jointly calling genotypes across multiple individuals based on linkage disequilibrium (LD) can facilitate the analysis of low to modest coverage sequence data. However, genotype-calling methods for family-based sequence data, particularly for complex families beyond parent-offspring trios, are still lacking.

As sequencing technologies can help researchers detect common and rare variants across the human genome in many individuals, it is known that jointly calling genotypes across multiple individuals based on linkage disequilibrium (LD) can facilitate the analysis of low to modest coverage sequence data. However, genotype-calling methods for family-based sequence data, particularly for complex families beyond parent-offspring trios, are still lacking.

Tags: