- Silberman Y, Fetterly TL, Awad EK, Milano EJ, Usdin TB, Winder DG. Ethanol produces corticotropin-releasing factor receptor-dependent enhancement of spontaneous glutamatergic transmission in the mouse central amygdala. Alcoholism, clinical and experimental research. 2015 Nov;39(11). 2154-62. PMID: 26503065 [PubMed]. PMCID: PMC4624256. NIHMSID: NIHMS718132.
Ethanol (EtOH) modulation of central amygdala (CeA) neurocircuitry plays a key role in the development of alcoholism via activation of the corticotropin-releasing factor (CRF) receptor (CRFR) system. Previous work has predominantly focused on EtOH × CRF interactions on the CeA GABA circuitry; however, our laboratory recently showed that CRF enhances CeA glutamatergic transmission. Therefore, this study sought to determine whether EtOH modulates CeA glutamate transmission via activation of CRF signaling.