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Molecular Physiology & Biophysics

Gene-wide analysis detects two new susceptibility genes for Alzheimer's disease.

AUTHORS

Escott-Price V , Bellenguez C , Wang LS , Choi SH , Harold D , Jones L , Holmans P , Gerrish A , Vedernikov A , Richards A , DeStefano AL , Lambert JC , Ibrahim-Verbaas CA , Naj AC , Sims R , Jun G , Bis JC , Beecham GW , Grenier-Boley B , Russo G , Thornton-Wells TA , Denning N , Smith AV , Chouraki V , Thomas C , Ikram MA , Zelenika D , Vardarajan BN , Kamatani Y , Lin CF , Schmidt H , Kunkle B , Dunstan ML , Vronskaya M , , Johnson AD , Ruiz A , Bihoreau MT , Reitz C , Pasquier F , Hollingworth P , Hanon O , Fitzpatrick AL , Buxbaum JD , Campion D , Crane PK , Baldwin C , Becker T , Gudnason V , Cruchaga C , Craig D , Amin N , Berr C , Lopez OL , De Jager PL , Deramecourt V , Johnston JA , Evans D , Lovestone S , Letenneur L , Hernández I , Rubinsztein DC , Eiriksdottir G , Sleegers K , Goate AM , Fiévet N , Huentelman MJ , Gill M , Brown K , Kamboh MI , Keller L , Barberger-Gateau P , McGuinness B , Larson EB , Myers AJ , Dufouil C , Todd S , Wallon D , Love S , Rogaeva E , Gallacher J , George-Hyslop PS , Clarimon J , Lleo A , Bayer A , Tsuang DW , Yu L , Tsolaki M , Bossù P , Spalletta G , Proitsi P , Collinge J , Sorbi S , Garcia FS , Fox NC , Hardy J , Naranjo MC , Bosco P , Clarke R , Brayne C , Galimberti D , Scarpini E , Bonuccelli U , Mancuso M , Siciliano G , Moebus S , Mecocci P , Zompo MD , Maier W , Hampel H , Pilotto A , Frank-García A , Panza F , Solfrizzi V , Caffarra P , Nacmias B , . PloS one. 2014 ; 9(6). e94661

ABSTRACT

Alzheimer’s disease is a common debilitating dementia with known heritability, for which 20 late onset susceptibility loci have been identified, but more remain to be discovered. This study sought to identify new susceptibility genes, using an alternative gene-wide analytical approach which tests for patterns of association within genes, in the powerful genome-wide association dataset of the International Genomics of Alzheimer’s Project Consortium, comprising over 7 m genotypes from 25,580 Alzheimer’s cases and 48,466 controls.

Alzheimer’s disease is a common debilitating dementia with known heritability, for which 20 late onset susceptibility loci have been identified, but more remain to be discovered. This study sought to identify new susceptibility genes, using an alternative gene-wide analytical approach which tests for patterns of association within genes, in the powerful genome-wide association dataset of the International Genomics of Alzheimer’s Project Consortium, comprising over 7 m genotypes from 25,580 Alzheimer’s cases and 48,466 controls.

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