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Molecular Physiology & Biophysics

Host and tumor derived MMP13 regulate extravasation and establishment of colorectal metastases in the liver.

AUTHORS

Mendonsa AM , VanSaun MN , Ustione A , Piston DW , Fingleton BM , Gorden DL , . Molecular cancer. 2015 ; 14(). 49

ABSTRACT

Non alcoholic fatty liver disease (NAFLD) is one of the most common liver diseases in the United States and worldwide. Our studies have previously shown an increase in metastatic burden in steatotic vs. normal livers using a mouse model of diet induced steatosis. In the present study we aim to identify and evaluate the molecular factors responsible for this increase in tumor burden.

Non alcoholic fatty liver disease (NAFLD) is one of the most common liver diseases in the United States and worldwide. Our studies have previously shown an increase in metastatic burden in steatotic vs. normal livers using a mouse model of diet induced steatosis. In the present study we aim to identify and evaluate the molecular factors responsible for this increase in tumor burden.

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