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Molecular Physiology & Biophysics

Macrophages are essential for CTGF-mediated adult β-cell proliferation after injury.

AUTHORS

Riley KG , Pasek RC , Maulis MF , Dunn JC , Bolus WR , Kendall PL , Hasty AH , Gannon M , . Molecular metabolism. 2015 8 ; 4(8). 584-91

ABSTRACT

Promotion of endogenous β-cell mass expansion could facilitate regeneration in patients with diabetes. We discovered that the secreted protein CTGF (aka CCN2) promotes adult β-cell replication and mass regeneration after injury via increasing β-cell immaturity and shortening the replicative refractory period. However, the mechanism of CTGF-mediated β-cell proliferation is unknown. Here we focused on whether CTGF alters cells of the immune system to enhance β-cell replication.

Promotion of endogenous β-cell mass expansion could facilitate regeneration in patients with diabetes. We discovered that the secreted protein CTGF (aka CCN2) promotes adult β-cell replication and mass regeneration after injury via increasing β-cell immaturity and shortening the replicative refractory period. However, the mechanism of CTGF-mediated β-cell proliferation is unknown. Here we focused on whether CTGF alters cells of the immune system to enhance β-cell replication.

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