Multiregion whole-exome sequencing of matched primary and metastatic tumors revealed genomic heterogeneity and suggested polyclonal seeding in colorectal cancer metastasis.
AUTHORS
Wei
Q ,
Ye
Z ,
Zhong
X ,
Li
L ,
Wang
C ,
Myers
RE ,
Palazzo
JP ,
Fortuna
D ,
Yan
A ,
Waldman
SA ,
Chen
X ,
Posey
JA ,
Basu-Mallick
A ,
Jiang
BH ,
Hou
L ,
Shu
J ,
Sun
Y ,
Xing
J ,
Li
B ,
Yang
H ,
. Annals of oncology : official journal of the European Society for Medical Oncology. 2017 9 1; 28(9). 2135-2141
- PMID: 28911083 [PubMed].
- PMCID: PMC5834069.
ABSTRACT
Distant metastasis accounts for 90% of deaths from colorectal cancer (CRC). Genomic heterogeneity has been reported in various solid malignancies, but remains largely under-explored in metastatic CRC tumors, especially in primary to metastatic tumor evolution.
Distant metastasis accounts for 90% of deaths from colorectal cancer (CRC). Genomic heterogeneity has been reported in various solid malignancies, but remains largely under-explored in metastatic CRC tumors, especially in primary to metastatic tumor evolution.
Tags: 2017