Vito Quaranta lab
My research focuses on identifying the sources of tumor recurrence in BRAF-mutant melanoma. Using ideas from evolution and ecology, I examine the contributions from clonal subpopulations within a tumor to the overall cell population response in drug. My goal is to identify and characterize clonal cancer cell populations based on proliferation and molecular profiling, and use this information to design rational drug treatment strategies in the clinic. To achieve this goal, I use a combination of mathematical modeling, bioinformatics, and cell proliferation assays for various melanoma cell lines in response to drugs.