Hope Woods
Lyon College
Jens Meiler lab
My projects will be focused on method development in Rosetta for membrane proteins along with application of Rosetta and other tools like molecular dynamics and machine learning to predict the impact of variants in KCNQ1. My goal for the method development project is to implement a membrane object into Rosetta that can be used to model membrane proteins in different lipid constructs like micelles, bicelles or nanodisc and to model aqueous pores into structures like channels and beta barrels. For classifying variants of KCNQ1 I plan to obtain more data through molecular dynamic simulations of KCNQ1 and implement this data as features to train an artificial neural network to classify variants of unknown significance.