Stephen Doster
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Achilles’ heel for kidney cancer
Feb. 28, 2019, 3:35 PM by Meredith Jackson Renal cell carcinoma (RCC) is an aggressive form of kidney cancer that tends to recur even after treatment with targeted cancer therapies or immunotherapies. One commonly mutated pathway in RCC and in all cancers is the PI3K-AKT signaling axis. P13K and AKT enzymes… Read MoreMar. 7, 2019
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Novel DNA repair mechanism preserves genome integrity: study
by Leigh MacMillan As David Cortez, PhD, tells the story of his research team’s latest discovery, he shakes his head in disbelief. “I’m just astounded,” said Cortez, Ingram Professor of Cancer Research and professor of Biochemistry. The investigators, led by postdoctoral fellow Kareem Mohni,… Read MoreMar. 1, 2019
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Activation of ATR for Distinct Signaling Functions
Reproduced under the Creative Commons Attribution Noncommercial Share Alike 4.0 International License from T. E. Bass and D. Cortez, (2019) J. Cell Biol., published February 12, DOI: 10.1083/jcb.201810058. Copyright 2019, Bass & Cortez. ATR (ataxia telangiectasia-mutated and Rad3-related) is a kinase well known for its role in the DNA damage… Read MoreFeb. 20, 2019
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Modulating stress circuits
Feb. 14, 2019, 12:00 PM by Leigh MacMillan (iStock) Stress contributes to psychiatric diseases including depression, eating disorders and addiction. Neurons that express the stress signal corticotropin releasing factor (CRF) in a brain region called the BNST are thought to promote negative responses to stress. Danny Winder, PhD,… Read MoreFeb. 15, 2019
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Adhesion protein optimizes border
Feb. 14, 2019, 10:45 AM by Leigh MacMillan (iStock) The epithelial cells that line the intestines build a specialized cell surface — the “brush border” — that processes and absorbs nutrients, and defends against pathogens. The brush border consists of thousands of finger-like membrane protrusions (microvilli) on each… Read MoreFeb. 15, 2019
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NIC Cancer Biology Consortium July 2019 Consortium
Hotel Accommodations Parking Campus Maps Searchable Vanderbilt Campus Map … Read MoreFeb. 11, 2019
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New target for chronic kidney disease
Jan. 31, 2019, 10:00 AM by Leigh MacMillan The kidney has a remarkable capacity to repair itself following acute injury, but maladaptive repair can lead to fibrosis (scarring) and chronic kidney disease. Craig Brooks, PhD, and collaborators at Harvard previously reported that after injury,… Read MoreFeb. 6, 2019
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Designing antibodies to fight the flu
Jan. 31, 2019, 10:30 AM by Bill Snyder (iStock) The influenza virus is an annual threat to public health around the world. Rapid changes in viral surface proteins (antigens), however, make it difficult to identify antibodies with broadly neutralizing activity against different influenza subtypes. Reporting in the… Read MoreFeb. 6, 2019
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Cell death pathway implicated in bone marrow failure
Jan. 31, 2019, 9:40 AM From left, Sandra Zinkel, MD, PhD, Christi Salisbury-Ruf, MS, Patrice Wagner, PhD, Jing Zou, MD, PhD, and Yuliya Hassan have linked a specific form of programmed cell death to myelodysplastic syndrome, a type of bone marrow failure. by Leigh MacMillan The production of blood cells… Read MoreFeb. 6, 2019