Stephen Doster

  • Vanderbilt University

    Achilles’ heel for kidney cancer

    Feb. 28, 2019, 3:35 PM by Meredith Jackson Renal cell carcinoma (RCC) is an aggressive form of kidney cancer that tends to recur even after treatment with targeted cancer therapies or immunotherapies. One commonly mutated pathway in RCC and in all cancers is the PI3K-AKT signaling axis. P13K and AKT enzymes… Read More

    Mar. 7, 2019

  • Vanderbilt University

    Novel DNA repair mechanism preserves genome integrity: study

    by Leigh MacMillan As David Cortez, PhD, tells the story of his research team’s latest discovery, he shakes his head in disbelief. “I’m just astounded,” said Cortez, Ingram Professor of Cancer Research and professor of Biochemistry. The investigators, led by postdoctoral fellow Kareem Mohni,… Read More

    Mar. 1, 2019

  • Vanderbilt University

    Activation of ATR for Distinct Signaling Functions

    Reproduced under the Creative Commons Attribution Noncommercial Share Alike 4.0 International License from T. E. Bass and D. Cortez, (2019) J. Cell Biol., published February 12, DOI: 10.1083/jcb.201810058. Copyright 2019, Bass & Cortez. ATR (ataxia telangiectasia-mutated and Rad3-related) is a kinase well known for its role in the DNA damage… Read More

    Feb. 20, 2019

  • Vanderbilt University

    Modulating stress circuits

    Feb. 14, 2019, 12:00 PM by Leigh MacMillan (iStock) Stress contributes to psychiatric diseases including depression, eating disorders and addiction. Neurons that express the stress signal corticotropin releasing factor (CRF) in a brain region called the BNST are thought to promote negative responses to stress. Danny Winder, PhD,… Read More

    Feb. 15, 2019

  • Vanderbilt University

    Adhesion protein optimizes border

    Feb. 14, 2019, 10:45 AM by Leigh MacMillan (iStock) The epithelial cells that line the intestines build a specialized cell surface — the “brush border” — that processes and absorbs nutrients, and defends against pathogens. The brush border consists of thousands of finger-like membrane protrusions (microvilli) on each… Read More

    Feb. 15, 2019

  • Vanderbilt University

    Women’s hormones play role in drug addiction, higher relapse rates

    Feb. 11, 2019

  • NIC Cancer Biology Consortium July 2019 Consortium

    NIC Cancer Biology Consortium July 2019 Consortium

    Hotel Accommodations   Parking   Campus Maps Searchable Vanderbilt Campus Map  … Read More

    Feb. 11, 2019

  • Vanderbilt University

    New target for chronic kidney disease

    Jan. 31, 2019, 10:00 AM by Leigh MacMillan The kidney has a remarkable capacity to repair itself following acute injury, but maladaptive repair can lead to fibrosis (scarring) and chronic kidney disease. Craig Brooks, PhD, and collaborators at Harvard previously reported that after injury,… Read More

    Feb. 6, 2019

  • Vanderbilt University

    Designing antibodies to fight the flu

    Jan. 31, 2019, 10:30 AM by Bill Snyder (iStock) The influenza virus is an annual threat to public health around the world. Rapid changes in viral surface proteins (antigens), however, make it difficult to identify antibodies with broadly neutralizing activity against different influenza subtypes. Reporting in the… Read More

    Feb. 6, 2019

  • Vanderbilt University

    Cell death pathway implicated in bone marrow failure

    Jan. 31, 2019, 9:40 AM From left, Sandra Zinkel, MD, PhD, Christi Salisbury-Ruf, MS, Patrice Wagner, PhD, Jing Zou, MD, PhD, and Yuliya Hassan have linked a specific form of programmed cell death to myelodysplastic syndrome, a type of bone marrow failure. by Leigh MacMillan The production of blood cells… Read More

    Feb. 6, 2019