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Vanderbilt team shows how stomach bug can trigger cancer

Jul. 12, 2019—Jul. 11, 2019, 9:32 AM This illustration shows the H. pylori bacterium and a close-up of its “injector” at the stomach lining. Researchers at Vanderbilt University and the University of Michigan in Ann Arbor have obtained the first high-resolution image of a molecular “machine” used by the insidious stomach bug Helicobacter pylori (H. pylori) to...

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Vanderbilt vaccine pioneer James Crowe honored with major science prize

Jul. 12, 2019—Vanderbilt vaccine pioneer James Crowe honored with major science prize Jul. 9, 2019, 8:57 AM by Bill Snyder James Crowe Jr., MD, director of the Vanderbilt Vaccine Center, will be honored today by the science and technology company Merck KGaA, Darmstadt, Germany for his contributions to developing new therapeutics and vaccines against some of the...

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International Association of Medical Science Educators honors Osheroff

Jul. 12, 2019—Jul. 8, 2019, 11:31 AM by Kathy Whitney Richard Vari, PhD, Senior Dean for Academic Affairs, Virginia Tech Carilion School of Medicine, and president of IAMSE, (left) presents the award to Neil Osheroff, PhD. Neil Osheroff, PhD, John G. Coniglio professor of Biochemistry, professor of Medicine and director of the Academy for Excellence in Education,...

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Cook part of clinical study testing drug that may prevent cancer metastasis

Jul. 12, 2019—Jul. 8, 2019, 3:42 PM Ingrid Mayer, MD, center, principal investigator of a clinical study testing a drug that may prevent cancer metastasis, with Vanderbilt drug repurposing program team members Robert Lavieri, PhD, and Meghan Joly, PhD. (photo by Joe Howell) by Leigh MacMillan A clinical study of a drug that may block cancer metastasis...

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Schney Receives Research to Prevent Blindness Award

Jul. 12, 2019—Jul. 1, 2019, 9:29 AM by Jessica Pasley Research to Prevent Blindness (RPB) recently awarded three grants to investigators in the Department of Ophthalmology to support research into the causes, treatment and prevention of blinding diseases. The Vanderbilt University School of Medicine Department of Ophthalmology received an RPB Unrestricted Grant, which provides $115,000 a year...

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This is why we can’t have nice things: How influenza impairs the host defense

Jul. 11, 2019—By Deborah Roby The influenza virus prevents its own destruction and causes virulence by a newly discovered method. The non-structural protein 1 (NS1) of the influenza A virus allows disease proliferation by binding a protein that activates the host’s immune reaction. The lab of Yi Ren, in collaboration with researchers at various U.S. and Chinese...

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Former Pharmacology chair Hardman remembered as gifted scientist, educator, mentor

Jul. 2, 2019—Jul. 2, 2019, 9:24 AM by Bill Snyder Joel Hardman, PhD Joel Hardman, PhD, an internationally recognized scientist and educator who chaired the Department of Pharmacology at Vanderbilt University School of Medicine from 1975 to 1990, died June 30, 2019 in Hoosick Falls, New York, after a lengthy illness. He was 85. Dr. Hardman’s research...

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Study points to importance of chromatin remodeling complex for β cell function

Jun. 28, 2019—By Lorena Infante Lara Research from the labs of Roland Stein (Molecular Physiology & Biophysics) and Chris Wright (Cell & Developmental Biology) suggests that the chromatin remodeling complex Swi/Snf, when bound to transcription factor Pdx1, is required for controlling the growth rate of the embryonic pancreas and for maintaining β cell identity in the adult organ. Our...

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Potential probe for early ovarian cancer

Jun. 20, 2019—Jun. 20, 2019, 8:00 AM by Anivarya Kumar Ovarian cancer is the fifth leading cause of cancer death in women and one of the most difficult malignancies to detect at an early stage. Emerging clinical evidence suggests that the enzyme cyclooxygenase-1 (COX-1) contributes significantly to tumorigenesis in ovarian cancer. Thus COX-1 could serve as a novel...

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Steroid binding to metabolic enzyme

Jun. 12, 2019—Jun. 12, 2019, 9:00 AM by Bill Snyder The human cytochrome P450 enzymes are responsible for metabolizing a variety of substances — from lipids (fats) and steroid hormones to drugs and toxic chemicals. One such enzyme, P450 17A1, generates androstenedione and dehydroepiandrosterone (DHEA), involved in the production of sex hormones. How the enzyme binds to...

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