Lorena Infante Lara
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How do you maintain a cellular structure without a membrane? Researchers find that synapses can use liquids to create functional separations
Researchers from the School of Medicine Basic Sciences found that, although synapses are not bound by a membrane, they are still able to maintain a nanostructure necessary for evoked neurotransmission with the help of a physicochemical phenomenon called liquid-liquid phase separation. Read MoreFeb. 6, 2025
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Developmental biologists discover how a critical protein shapes gallbladder formation
Researchers from the School of Medicine Basic Sciences have discovered that the concentration of a critical protein influences the formation of the gallbladder and the bile duct system. Read MoreJan. 30, 2025
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Warren Center for Neuroscience Drug Discovery researchers create new compound to potentially treat negative and positive symptoms of schizophrenia
Researchers from the Warren Center for Neuroscience Drug Discovery, in collaboration with Boehringer Ingelheim, developed a compound that can treat both negative and positive symptoms of schizophrenia in rodents. The compound holds promise as an investigational tool and an inspiration for novel schizophrenia therapies. Read MoreJan. 16, 2025
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Fall 2024 Class Notes
Our School of Medicine Basic Sciences alums go far and wide. Check out the latest accomplishments from some of our alums! Read MoreDec. 11, 2024
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Research Snapshot: Spectroscopy and AI method provide unique window into protein structure and mechanism of action
Alexandra C. Schwartz, a recent Ph.D. graduate from the Chemical and Physical Biology Program, and colleagues developed an experimental and artificial intelligence–coupled methodology to explore the structural dynamics of membrane proteins. Read MoreDec. 2, 2024
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Vanderbilt researchers find evidence that the hunger hormone leptin can direct neural development in a leptin receptor–independent manner
Researchers from the lab of Richard Simerly have uncovered the first example of activity-dependent development of hypothalamic neural circuitry. The work also suggests a novel role for the hunger hormone leptin in specifying the development of neural circuits involved in autonomic regulation and food intake. Read MoreNov. 25, 2024
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Faculty transitions
The academic landscape can seem like an unmoving entity, but it’s the people within it that make it tick and grow to new frontiers. No outlook on our School of Medicine Basic Sciences is complete without recognizing significant faculty transitions, including well-deserved promotions, exciting new appointments, and bittersweet departures as… Read MoreNov. 22, 2024
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New structure gives insight into mRNA export and cancers, and how viruses hijack the process to infect their host
A newly determined structure from the lab of Yi Ren reveals information about the mRNA export pathway and suggests that herpes viruses could hijack that interaction to infect their host. The new structures also reveal how certain mutations in the protein complex could play a role in cancers. Read MoreNov. 14, 2024
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Determining the precise timing of cellular growth to understand the origins of cancer
Mirazul Islam, a graduate student in the lab of Professor Ken Lau, has developed a molecular clock that records the timing of cellular events at a single-cell resolution. Read MoreOct. 31, 2024
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Drug discovery efforts continue in latest chemical chronicle from the Warren Center for Neuroscience Drug Discovery
Led by Craig W. Lindsley, Vanderbilt drug discovery experts set out to develop a backup drug candidate to improve memory loss in people with Alzheimer’s disease. Read MoreOct. 15, 2024