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The highly complex process of DNA replication is susceptible to a large number of stressors that can lead to stalling, and ultimately collapse, of the replication fork. The cell has multiple pathways to repair stalled forks, enabling DNA synthesis to proceed, but failure to achieve this goal leads to genomic… Read More

Accumulating evidence indicates that cancer is the result of multiple genetic mutations that lead to dysregulated cell signaling, growth, and death. This knowledge has led to the discovery of an exciting new armamentarium of therapies intended to disrupt the abnormal cellular responses that result from cancer-associated gene mutations. However, these… Read More

A primary function of the lining surface of the intestine is to absorb nutrients. The epithelial cells that form this surface are notable for the presence of a brush border composed of microvilli, tiny plasma membrane projections that markedly increase the surface area through which absorption can take place. Read More

Pitt Hopkins syndrome (PTHS) is a rare neurodevelopmental disorder characterized by a characteristic facial appearance, poor muscle tone and coordination, unusual breathing patterns, delayed development, and a profound language impairment. The cause is haploinsufficiency of the gene for transcription factor 4 (Tcf4), a gene that has also been associated… Read More

Cystic fibrosis is a genetic disorder associated with recurrent lung infections, poor digestion, stunted growth, and a shortened life expectancy. It is caused by mutation of the gene that encodes the cystic fibrosis transmembrane conductance regulator protein (CFTR), which transports chloride ion across the apical membranes of epithelial cells,… Read More

Heidi Hamm, Ph.D., Ana Carneiro, Ph.D., and colleagues used pharmacological and genetic models to show that chronic SSRI treatment causes decreased levels of a serotonin receptor (5-HT2AR) on platelets. They showed that inhibiting SERT increases extracellular serotonin, which desensitizes the 5-HT2AR and reduces platelet activation. Read More

Colleagues of Vivien Casagrande, Ph.D., celebrated her distinguished career in the visual sciences with a “Lifetime of Vision” symposium Nov. 18 in Biological Sciences/Medical Research Building III. Casagrande, who joined the Vanderbilt University faculty in 1975, is professor of Cell & Developmental Biology, Ophthalmology and Visual Sciences and… Read More

In a new study, Vanderbilt pharmacologist Jerod Denton, Ph.D., Ohio State entomologist Peter Piermarini, Ph.D., and colleagues report an experimental molecule that inhibits kidney function in mosquitoes and thus might provide a new way to control the deadliest animal on Earth. Read More

Vanderbilt University School of Medicine (VUSM) has formed a new Basic Science Research Advisory Committee. The committee, which is inclusive across all VUSM departments, will hold quarterly meetings that will serve as a forum for generating ideas and opportunities. The committee’s first meeting will take place on Dec. Read More

Aptamers are short RNA or RNA-based polynucleotides that are designed to bind tightly and specifically to a target protein. They have engendered considerable excitement in recent years because of their potential uses as drugs, diagnostic probes, and research affinity agents. In fact, an aptamer that binds to vascular endothelial… Read More