Cryo-electron Microscopy
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STOP the GAP: New cryo-ET package aims to fill in the ‘missing wedge’
Cryo-ET suffers from the “missing wedge” problem: as samples become more tilted, their thickness at the extremes is increased and sample penetration decreases. William Wan and collaborators describe the creation of a new subtomogram averaging package called STOPGAP. Read MoreJun. 3, 2024
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Cryo-EM reveals the molecular mechanism of IP3 receptor channel opening
Research led by co-first authors Emily Schmitz, a graduate student in the Chemical and Physical Biology program, and Hirohide Takahashi, a research instructor in molecular physiology and biophysics, identified the structure of the human type-3 inositol 1,4,5-triphosphate, or IP3, receptor in several conformations using cryo-electron microscopy. Schmitz and Takahasi, who… Read MoreMay. 9, 2022