Discovery
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Profiling chromatin accessibility and DNA methylation—simultaneously
Research led by Emily Hodges, assistant professor of biochemistry, first-author Lindsey Guerin, a graduate student in the Hodges lab, and Kelly Barnett, a recent graduate of the Hodges lab, developed and tested a new method called ATAC-Me, which profiles multiple epigenetic features, including DNA methylation, simultaneously from a single DNA… Read MoreFeb. 1, 2022
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Flipping the script on flippases
Todd Graham, Stevenson Chair of Biological Sciences and professor of cell and developmental biology, and external collaborators recently published a paper describing the structure of a yeast “flippase” called Neo1. The research was led by three co-first authors: Bhawik Jain, a postdoc from the Graham lab, Lin Bai from Peking… Read MoreDec. 6, 2021
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Calipari named Dean’s Faculty Fellow
Erin Calipari, assistant professor of pharmacology and member of the Vanderbilt Center for Addiction Research, has been named a Dean’s Faculty Fellow of the School of Medicine Basic Sciences. The Dean’s Faculty Fellows program, started in 2020, is designed to recognize the efforts of faculty in the early stages of… Read MoreDec. 1, 2021
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Burkewitz awarded $100,000 to conduct longevity research at the cellular level
Kristopher Burkewitz, assistant professor of cell and developmental biology, has been awarded $100,000 from the American Federation for Aging Research and the Glenn Foundation for Medical Research to research the biological aging process. Burkewitz was one of 10… Read MoreNov. 22, 2021
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Mosquitoes have a mutual symbiotic relationship with malaria-causing pathogen
Cornelius Vanderbilt Professor of Biological Sciences Laurence J. Zwiebel is part of a team of researchers at Vanderbilt and the Johns Hopkins Malaria Research… Read MoreNov. 19, 2021
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Professor makes Vanderbilt-discovered cancer targeting molecule freely available to researchers through collaboration with Boehringer Ingelheim
Stephen Fesik, Orrin H. Ingram II Chair in Cancer Research, has conducted pioneering research on some of the most difficult drug discovery targets in cancer research. As a result of his lab’s discoveries, molecule-specific data has been made freely available for download to cancer researchers on the opensource platform opnMe.com, which… Read MoreNov. 15, 2021
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New target identified for rapid antidepressant drugs
THE IDEA Vanderbilt researchers found that ketamine’s rapid antidepressant action is due to specific synaptic effects. This represents a new target for drug development that could fill a major gap in care for depression. Ege Kavalali (Vanderbilt University) Lisa Monteggia (John Russell/Vanderbilt University) The research was led by… Read MoreNov. 10, 2021
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Finding a resistance to obesity
By Wendy Bindeman L-R: Sheila Collins, Ryan Ceddia A trans-institutional team that includes Professor of Medicine and Molecular Physiology and Biophysics Sheila Collins, first author and Collins lab postdoc Ryan Ceddia, and Johns Hopkins collaborators Dr. David Kass and Sumita Mishra recently published a study showing that mice lacking an… Read MoreNov. 9, 2021
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Discovery shows how synapses are built and function in the nervous system
Nerve cells in the brain establish connections or synapses to form complex electrical circuits that keep people thinking and moving. Despite the importance of these synapses in mediating the flow of charged particles between neurons, not much is understood about how these connections are created. Sierra Palumbos David Miller Research… Read MoreNov. 8, 2021
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A new regulator of fat metabolism
By Wendy Bindeman Sheila Collins, professor of medicine. Sheila Collins, who is a professor of medicine and has a secondary appointment in molecular physiology and biophysics, first author Fubiao Shi, a postdoctoral fellow in the Collins lab, and colleagues have recently identified the transcription factor PPARγ as a novel regulator… Read MoreNov. 3, 2021