Galina Lepesheva

Acanthamoeba can cause diseases blinding keratitis, an infection of the eye, or granulomatous amebic encephalitis, a generally fatal infection of the brain and spinal cord. Antifungals that target the biosynthesis of fungal sterols, such as ergosterol, are often used as treatment, but the Acanthamoeba ergosterol biosynthetic pathway has been shown to differ significantly from that found in fungi. Read More