Robert Coffey

Ken Lau, professor of cell and developmental biology, and colleagues have laid out the principles governing the biology of early, precancerous lesions, which are different from the principles that govern cancers. Their authoritative perspective was published in Cancer Discovery in April 2024. Read More

Cells in the body communicate by sending and receiving protein and genetic information packaged in extracellular vesicles and nanoparticles, including exomeres and supermeres. This complex transport system is important not only in health, but in disorders as diverse as cancer, cardiovascular disease and Alzheimer’s disease. For example,… Read More

Vanderbilt University Medical Center has received a five-year, $5 million grant from the National Cancer Institute to study precancerous lesions and early cancers in the colon, with the goal of developing new ways to prevent colorectal cancer, the nation’s second leading cancer killer. Robert Coffey, MD, Martha Shrubsole, PhD, and Ken… Read More

Treatment resistance is especially pronounced in gastric cancer and contributes to patient mortality, highlighting the need for resensitization strategies. Robert Coffey, MD, Xiaodi Zhao, PhD, and colleagues compared the secretome, or secreted proteins, of chemoresistant and chemosensitive human gastric cancer cell lines to identify biomarkers of resistance. Read More