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Research from Teru Nakagawa, professor of molecular physiology and biophysics, describes intricacies of normal brain function with implications for our understanding of brain injury and recovery: A decrease in pH can modify a neurotransmitter receptor’s structure, thereby modulating its location and kinetics. Read More

In a recent episode of Smarter Every Day, YouTube sensation and host Destin Sandlin talks with Vanderbilt Professor Tina Iverson and Senior Research Associate Prashant Singh about bacterial “motors” and how they work in the microorganisms that make us sick. The video racked up more than 1.4 million views in its first day. Read More

A drug discovery project to mitigate cardiovascular inflammation headed by Sean Davies and Amanda Doran receives funding injection from the School of Medicine Basic Sciences and the Office of the Vice Provost for Research and Innovation.  Read More

Researchers from the School of Medicine Basic Sciences recently developed an analytical tool called EV Fingerprinting that could lead to the use of “liquid biopsies” as a substitute for traditional biopsies for certain patients or diseases. Read More

Through the ASPIRE on the Road program, the Office of Biomedical Research Education and Training office took 12 biomedical trainees from Vanderbilt University to explore Boston’s small and large biotech companies. Read More

It started with a hacksaw and a multimillion-dollar instrument. Richard Caprioli, then a postdoctoral fellow, was given the saw to cut the instrument in half during his first day of his postdoctoral studies. It was the day that Caprioli, now Stanford Moore Professor of Biochemistry, developed a desire to “do innovative things” with mass spectrometry instruments.” This yearning resulted in him becoming a pioneer of new mass spec techniques, including imaging mass spec. Read More

The Warren Center for Neuroscience Drug Discovery opened its doors to the Nashville community to share firsthand the pioneering work it is conducting on Alzheimer’s disease, Parkinson’s disease, addiction, and more. Read More

Vanderbilt researchers have identified cancer cell-specific genetic alterations that reprogram the immune “landscape,” thereby driving tumor growth, and discovered a potential new drug target for stopping it. Read More

By targeting a notoriously undruggable protein found in many cancers, the discovery of BI-0474 may pave the way for new cancer treatments. Shared on opnMe.com by Boehringer Ingelheim, this innovative molecule is available for global researchers to explore new research avenues. Read More

Benjamin P. Brown, assistant professor of pharmacology, and colleagues in the departments of molecular physiology and biophysics, pharmacology, and chemistry, have determined that AlphaFold2 can be used to generate approximations of relative conformational preferences of proteins, which will help researchers better understand a protein’s structure and function across a range of conditions and mutational states. Read More