Vanderbilt Basic Sciences

  • Vanderbilt University

    A new view of a cholesterol carrier

    High density lipoprotein (HDL) is often referred to as “good cholesterol.” However, cholesterol is just one of many types of cargo HDL can carry. In addition to shuttling cholesterol from blood to the liver, high-density lipoprotein (HDL) can also transport proteins, metabolites and small RNAs (sRNA). The discovery of HDL’s… Read More

    Feb. 10, 2023

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    Five Vanderbilt faculty elected as 2022 American Association for the Advancement of Science fellows

    Five Vanderbilt University and Vanderbilt University Medical Center faculty members were elected as 2022 fellows of the American Association for the Advancement of Science. They were selected by a group of their AAAS peers.   “The ranks of AAAS fellows include the likes of W.E.B. Du Bois,… Read More

    Feb. 3, 2023

  • Headshot of Anne Hatmaker.

    Diversity in infectious mold species impacts respiratory disease severity in humans

    By Caroline Cencer Anne Hatmaker Fungal diseases caused by pathogenic fungi such as molds affect millions of people worldwide every year. Despite the high prevalence of fungal diseases, the mechanism of infection is not well understood. The laboratory of Professor of Biological Sciences Antonis Rokas, led by graduate student Anne… Read More

    Feb. 3, 2023

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    Nutrient absorption disease model

    Mutations in the gene MYO5B cause microvillus inclusion disease (MVID), which prevents nutrient absorption in the intestines and is characterized by severe watery diarrhea that typically starts in the first hours after birth. People with MVID usually require lifelong intravenous feedings (parenteral nutrition) or small bowel transplantation. … Read More

    Feb. 2, 2023

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    Study identifies human proteins with segments devoid of genetic variation

    By Leah Mann Charles Sanders, Ph.D. The lab of Charles Sanders, professor of biochemistry and the Aileen M. Lange and Annie Mary Lyle Chair for Cardiovascular Research, published a study in Protein Science identifying all human proteins that have at least one segment that does not have… Read More

    Jan. 27, 2023

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    The Expert from Nowhere

    To understand a protein’s structure is to understand its function, says structural and chemical biologist Jens Meiler, PhD, distinguished research professor of Chemistry. It can take a PhD student up to five sleep-deprived years to determine the structure of a single protein, and of the 20,000 human proteins, only about… Read More

    Jan. 26, 2023

  • Headshot of Wenbiao Chen.

    CRISPR screen identifies role for a specific protein in insulin secretion

    By Leah Mann Wenbiao Chen, Ph.D. The labs of Wenbiao Chen, associate professor of molecular physiology and biophysics, and Irina Kaverina, professor of cell and development biology, recently published a study in Molecular Metabolism focused on detecting genes that regulate insulin secretion. The authors demonstrated a new… Read More

    Jan. 25, 2023

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    Estrada to lead VUSM health equity education

    Lourdes Estrada, PhD, associate professor of Biochemistry, has been named assistant dean for Health Equity Education, Vanderbilt University School of Medicine, effective Feb. 1. In this role, she will work to develop and expand initiatives that integrate core principles of health equity into VUSM’s health sciences educational programs, with an… Read More

    Jan. 19, 2023

  • Vanderbilt University Basic Sciences Jeffrey Rathmell, PhD, has been named to receive a distinguished innovator award from the Lupus Research Alliance.

    Study identifies potential new approach for treating lupus

    Targeting iron metabolism in immune system cells may offer a new approach for treating systemic lupus erythematosus (SLE) — the most common form of the chronic autoimmune disease lupus. A multidisciplinary team of investigators at Vanderbilt University Medical Center has discovered that blocking an iron uptake receptor reduces disease pathology… Read More

    Jan. 19, 2023

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    New screening method could pave the way for future cancer drug discoveries

    The laboratories of Brian Bachmann, professor of chemistry, biochemistry and pharmacology, and Jonathan Irish, associate professor of cell and developmental biology and pathology, microbiology and immunology, have developed a method to discover new small molecules that may kill cancer cells by working through the body’s immune system. The method is… Read More

    Jan. 18, 2023