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School of Medicine Basic Sciences

Department of Biochemistry

Biochemistry is part of Basic Sciences in the Vanderbilt University School of Medicine. Basic Sciences is comprised of the departments biochemistry, cell and developmental biology, pharmacology, and molecular physiology and biophysics. Learn more about our thriving research community by clicking the buttons below.

 

 

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What is Biochemistry?

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The Department of Biochemistry is dedicated to discovering the fundamental mechanisms of biological processes, bridging these discoveries with clinical applications to improve human health, and training the next generation of biomedical scientists. Our investigators are leaders in applying advanced approaches in structural biology, mass spectrometry, chemical biology, cell biology, and genetics to thematic areas like DNA and RNA metabolism, cell division, enzymology, molecular cancer biology, signaling, toxicology, and metabolism. We are united in seeking molecular answers to biomedical questions. 

The Department has 26 primary investigator-track faculty and another ~50 secondary, educator, and research-track faculty. An exceptional group of graduate, medical, and undergraduate students and large cohort of post-doctoral fellows train in our laboratories supported by over $30M in funding. 

As one of four basic science departments in the School of Medicine Basic Sciences, Biochemistry benefits from being affiliated with a large medical center and medical school as well as Colleges of Arts and Sciences, Engineering, and Connected Computing. Our unique structure allows us to strategically invest in infrastructure, initiatives, and people to fulfill our missions of research, education, and service. 

Biochemistry investigators have received major awards including election to the National Academy of Sciences, and a Nobel Prize in Physiology or Medicine (Stanley Cohen, 1986). Our culture of excellence, collaboration, innovation, rigor, dedication, inclusiveness, ambition, kindness, and resiliency facilitates high impact research, education, and service. – David Cortez, Chair 

We invite queries regarding graduate studies, postdoctoral training, and faculty positions.

A recent article about the Biochemistry Department can be found here.

Biochemistry Announcements

Biochemistry News

A molecular blueprint for bacterial DNA repair

August 27, 2026-Every day, the DNA of living organisms is exposed to damage from normal cellular processes, environmental toxins, and even some medicines. Among the most dangerous forms of damage are interstrand DNA crosslinks (ICLs), chemical bonds that effectively staple the two strands of DNA together and prevent cells from reading, copying, or repairing their genetic information.

While scientists have long known that bacteria possess mechanisms to repair these lesions, exactly how they recognize and remove them has remained unclear.

In a new study, the Eichman lab and the Skaar lab provide the first detailed structural view of AlkX, a DNA repair enzyme found in several disease-causing bacteria, revealing how it detects and repairs these potentially lethal DNA crosslinks.

Researchers create tool to explore the formation and function of cell membrane structures called lipid rafts

August 27, 2026-Animal cell membranes are like vast oceans where phospholipids are “water” and clusters of other specialized lipids, carbohydrates, and proteins are “rafts” floating about. These lipid rafts help cells maintain order within their membranes, which plays an integral role in cellular function.

A recent paper from the lab of Charles Sanders, the Aileen M. Lange and Annie Mary Lyle Professor of Cardiovascular Research and a professor of biochemistry, describes the discovery of two small molecules that can affect the stability of these rafts, which will help researchers study their function.

We checked in with Sanders, who told us more about the research.

When a scientist gets cancer

July 23, 2026-Larry Marnett (Biochemistry) spent his career decoding cancer’s secrets. 

In this article, he chronicles his own battle with the disease, blending clinical insight with the realities of treatment. 
10 years SOMBS

Looking to become a biochemistry undergraduate major?

Contact the Biochemistry and Chemical Biology Undergraduate Major Program at https://as.vanderbilt.edu/biochemistry-chemical-biology/