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Lucy X. Lua, Maria Rosa Domingo-Sananesb, Malwina Huzarskaa, Bela Novakb, and Kathleen L. Gould a,c,1 + Author Affiliations a Department of Cell and Developmental Biology, and c The Howard Hughes Medical Institute, Vanderbilt University School of Medicine, Nashville, TN 37212; and b Oxford Centre for Integrative Systems Biology,… Read More

oojitha Sitaram, Michael A. Anderson*, Jeanne N. Jodoin, Ethan Lee and Laura A. Lee‡ + Author Affiliations Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, U-4225 Medical Research Building III, 465 21st Avenue South, Nashville, TN 37232-8240, USA. + Author Notes * Present address: Georgetown University Law… Read More

The fission yeast septation initiation network (SIN) kinase, Sid2, is required for SIN asymmetry and regulates the SIN scaffold, Cdc11 Anna Feoktistovaa, Jennifer Morrell-Falveya, Jun-Song Chena, N. Sadananda Singh, Mohan K. Balasubramanianb,c, and Kathleen L. Goulda,1 + Affiliations aHoward Hughes Medical Institute and Department of Cell and Developmental Biology, Vanderbilt… Read More

beta-catenin accumulates in the nucleus and binds to the transcription factor, TCF/Lef, to activate Wnt target gene transcription. In order for beta-catenin to bind TCF/Lef, however, the transcriptional corepressor Groucho (Gro)/TLE, which is bound to TCF/Lef, must be displaced. Work by Hanson et al. shows that X-linked Inhibitor of Apoptosis… Read More

Enteric nervous system specific deletion of Foxd3 disrupts glial cell differentiation and activates compensatory enteric progenitors Abstract The enteric nervous system (ENS) arises from the coordinated migration, expansion and differentiation of vagal and sacral neural crest progenitor cells. During development, vagal neural crest cells enter the foregut and… Read More

Info: Enterocyte Microvillus-Derived Vesicles Detoxify Bacterial Products and Regulate Epithelial-Microbial Interactions David A. Shifrin, Jr., Russell E. McConnell, Rajalakshmi Nambiar, James N. Higginbotham, Robert J. Coffey, and Matthew J. Tyska Current Biology; April 10, 2012 Abstract: The continuous monolayer of intestinal epithelial cells (IECs) lining the… Read More

Concerted effort of centrosomal and Golgi-derived microtubules is required for proper Golgi complex assembly but not for maintenance Abstract Assembly of an integral Golgi complex is driven by microtubule (MT)-dependent transport. Conversely, the Golgi itself functions as an unconventional MT-organizing center (MTOC). This raises the question of whether… Read More

In humans, GLE1 is mutated in lethal congenital contracture syndrome 1 (LCCS1) leading to prenatal death of all affected fetuses. Although the molecular roles of Gle1 in nuclear mRNA export and translation have been documented, no animal models for this disease have been reported. To elucidate the function of Gle1… Read More

One of the most abundant components of the enterocyte brush border is the actin-based monomeric motor, myosin-1a (Myo1a). Within brush border microvilli, Myo1a carries out a number of critical functions at the interface between membrane and actin cytoskeleton. Proper physiological function of Myo1a depends on its ability to bind to… Read More

"In November 2011, the AAAS Council elected 539 members as Fellows of AAAS. These individuals will be recognized for their contributions to science and technology at the Fellows Forum to be held on 18 February 2012 during the AAAS Annual Meeting in Vancouver, Canada. The new Fellows will receive a… Read More