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Molecular Design and Synthesis Center

Publications

“2024”

MartinezLA, ImamiA, de JongE, RomaineIM, ZwiebelLJ, Binary mixtures of Vanderbilt University allosteric agonist thermolysis components act as volatile spatial repellents for malaria vector mosquitoesPest management science. 2024 Sep 22
Carvajal-GarciaJ, BraceyH, JohnsonAE, Hernandez VieraAJ, EgliM, SimsekEN, JarembaEA, KimK, MerrikhH, A small molecule that inhibits the evolution of antibiotic resistanceNAR molecular medicine. 2024 Jan 23 1 (1). ugae001
PastoraLE, NamburuNS, AroraK, ChristovPP, WilsonJT, STING-Pathway Inhibiting Nanoparticles (SPINs) as a Platform for Treatment of Inflammatory DiseasesACS applied bio materials. 2024 Apr 2
BaljonJJ, KwiatkowskiAJ, PagendarmHM, StonePT, KumarA, BhartiV, SchulmanJA, BeckerKW, RothEW, ChristovPP, JoyceS, WilsonJT, A Cancer Nanovaccine for Co-Delivery of Peptide Neoantigens and Optimized Combinations of STING and TLR4 AgonistsACS nano. 2024 Feb 22 18 (9). 6845-6862
HawesEM, RahimM, HaratipourZ, OrunAR, O'RourkeML, OeserJK, KimK, ClaxtonDP, BlindRD, YoungJD, O'BrienRM, Biochemical and metabolic characterization of a G6PC2 inhibitorBiochimie. 2024 Mar 1 222 109-122
WonY, JangB, LeeSH, ReyzerML, PresentationKS, KimH, CaldwellB, ZhangC, LeeHS, LeeC, TrinhVQ, TanMCB, KimK, CaprioliRM, ChoiE, Oncogenic Fatty Acid Metabolism Rewires Energy Supply Chain in Gastric CarcinogenesisGastroenterology. 2024 Jan 24

“2023”

FuY, ChristovPP, KingsleyPJ, Richie-JannettaRM, MarnettLJ, StoneMP, Base-Displaced Intercalated Structure of the 3-(2-Deoxy-β-D-erythropentofuranosyl)-pyrimido[1,2-]purine-6,10(3,5)-dione (6-oxo-MdG) Lesion in DNAChemical research in toxicology. 2023 Nov 21 36 (12). 1947-1960
Wang-BishopL, KimmelBR, NgwaVM, MaddenMZ, BaljonJJ, FlorianDC, HannaA, PastoraLE, SheehyTL, KwiatkowskiAJ, WehbeM, WenX, BeckerKW, GarlandKM, SchulmanJA, ShaeD, EdwardsD, WolfMM, DelappR, ChristovPP, BeckermannKE, BalkoJM, RathmellWK, RathmellJC, ChenJ, WilsonJT, STING-activating nanoparticles normalize the vascular-immune interface to potentiate cancer immunotherapyScience immunology. 2023 May 5 8 (83). eadd1153
SiricillaS, HansenCJ, RogersJH, DeD, SimpsonCL, WatersonAG, SulikowskiGA, CrockettSL, BoatwrightN, ReeseJ, PariaBC, NewtonJ, HeringtonJL, Arrest of mouse preterm labor until term delivery by combination therapy with atosiban and mundulone, a natural product with tocolytic efficacyPharmacological research. 2023 Aug 1 195 106876
ZarrowJE, Alli-OluwafuyiAM, YouwakimCM, KimK, JenkinsAN, SueroIC, JonesMR, MashhadiZ, MackieK, WatersonAG, DoranAC, SulikowskiGA, DaviesSS, Small Molecule Activation of NAPE-PLD Enhances Efferocytosis by MacrophagesACS chemical biology. 2023 Aug 2 18 (8). 1891-1904
Benzothiazolylphenylsulfonylpiperidine derivatives as N-acylphosphatidylethanolamine hydrolyzing phospholipase D activators and their preparationWO2023201014.

    “2022”

    Prael IiiFJ, KimK, DuY, SpitznagelBD, SulikowskiGA, DelpireE, WeaverCD, Discovery of Small Molecule KCC2 Potentiators Which Attenuate Seizure-Like Activity in Cultured NeuronsFrontiers in cell and developmental biology. 2022 Jun 24 10 912812
    KellyKP, BorsettiH, WenzlerME, UstioneA, KimK, ChristovPP, RamirezB, BauerJA, PistonDW, JohnsonCH, SulikowskiGA, Screen for Small-Molecule Modulators of Circadian Rhythms Reveals Phenazine as a Redox-State Modifying Clockwork TunerACS chemical biology. 2022 Jun 9
    XuJ, SunX, KimK, BrandRM, HartmanD, MaH, BrandRE, BaiM, LiuY, Ultrastructural visualization of chromatin in cancer pathogenesis using a simple small-molecule fluorescent probeScience advances. 2022 Mar 4 8 (9). eabm8293
    ÇakırI, HadleyCK, PanPL, BagchiRA, Ghamari-LangroudiM, PorterDT, WangQ, LittMJ, JanaS, HagenS, LeeP, WhiteA, LinJD, McKinseyTA, ConeRD, Histone deacetylase 6 inhibition restores leptin sensitivity and reduces obesityNature metabolism. 2022 Jan 17 4 (1). 44-59

    “2021”

    ZarrowJE, TianJ, DutterB, KimK, DoranAC, SulikowskiGA, DaviesSS, Selective measurement of NAPE-PLD activity via a PLA-resistant fluorogenic N-acyl-phosphatidylethanolamine analogJournal of lipid research. 2021 Nov 26 100156
    ChristovPP, Richie-JannettaR, KingsleyPJ, VemulapalliA, KimK, SulikowskiGA, RizzoCJ, KetkarA, EoffRL, RouzerCA, MarnettLJ, Site-Specific Synthesis of Oligonucleotides Containing 6-Oxo-MdG, the Genomic Metabolite of MdG, and Liquid Chromatography-Tandem Mass Spectrometry Analysis of Its In Vitro Bypass by Human Polymerase ιChemical research in toxicology. 2021 Dec 3 34 (12). 2567-2578
    KozlyukN, GilstonBA, SalayLE, GogliottiRD, ChristovPP, KimK, OveeM, WatersonAG, ChazinWJ, A Fragment-Based Approach to Discovery of RAGE InhibitorsProteins. 2021 Jun 22
    ChristovPP, KimK, JanaS, RomaineIM, RaiG, MottBT, AllweilAA, LamersA, BrimacombeKR, UrbanDJ, LeeTD, HuX, LukacsCM, DaviesDR, JadhavA, HallMD, GreenN, MooreWJ, StottGM, FlintAJ, MaloneyDJ, SulikowskiGA, WatersonAG, Optimization of ether and aniline based inhibitors of lactate dehydrogenaseBioorganic & medicinal chemistry letters. 2021 Mar 24 41 127974
    KimK, ChristovPP, RomaineI, TianJ, JanaS, LamersAP, DutterBF, ScaggsT, JeonK, GuttentagB, WeaverCD, LindsleyCW, WatersonAG, SulikowskiGA, Ten-Year Retrospective of the Vanderbilt Institute of Chemical Biology Chemical Synthesis CoreACS chemical biology. 2021 Apr 20
    WehbeM, Wang-BishopL, BeckerKW, ShaeD, BaljonJJ, HeX, ChristovP, BoydKL, BalkoJM, WilsonJT, Nanoparticle delivery improves the pharmacokinetic properties of cyclic dinucleotide STING agonists to open a therapeutic window for intravenous administrationJournal of controlled release : official journal of the Controlled Release Society. 2020 Nov 12 330 1118-1129
    NguyenDC, ShaeD, PagendarmHM, BeckerKW, WehbeM, KilchristKV, PastoraLE, PalmerCR, SeberP, ChristovPP, DuvallCL, WilsonJT, Amphiphilic Polyelectrolyte Graft Copolymers Enhance the Activity of Cyclic Dinucleotide STING AgonistsAdvanced healthcare materials. 2020 Nov 23 10 (2). e2001056

    “2020”

    RaiG, UrbanDJ, MottBT, HuX, YangSM, BenavidesGA, JohnsonMS, SquadritoGL, BrimacombeKR, LeeTD, CheffDM, ZhuH, HendersonMJ, PohidaK, SulikowskiGA, DranowDM, KabirM, ShahP, PadilhaE, TaoD, FangY, ChristovPP, KimK, JanaS, MuttilP, AndersonT, KundaNK, HathawayHJ, KusewittDF, OshimaN, CherukuriM, DaviesDR, NorenbergJP, SklarLA, MooreWJ, DangCV, StottGM, NeckersL, FlintAJ, Darley-UsmarVM, SimeonovA, WatersonAG, JadhavA, HallMD, MaloneyDJ, Pyrazole-Based Lactate Dehydrogenase Inhibitors with Optimized Cell Activity and Pharmacokinetic PropertiesJournal of medicinal chemistry. 2020 Sep 27 63 (19). 10984-11011
    JuttukondaLJ, BeaversWN, UnsihuayD, KimK, PishchanyG, HorningKJ, WeissA, Al-TameemiH, BoydJM, SulikowskiGA, BowmanAB, SkaarEP, A Small-Molecule Modulator of Metal Homeostasis in Gram-Positive PathogensmBio. 2020 Oct 27 11 (5).
    KimbroughJR, JanaS, KimK, AllweilA, OatesJA, MilneGL, SulikowskiGA, Synthesis of tetranor-PGE: a urinary metabolite of prostaglandins E and ETetrahedron letters. 2020 Apr 10 61 (22).
    HorningKJ, JoshiP, NitinR, BalachandranRC, YankoFM, KimK, ChristovP, AschnerM, SulikowskiGA, WeaverCD, BowmanAB, Identification of a selective manganese ionophore that enables nonlethal quantification of cellular manganeseThe Journal of biological chemistry. 2020 Feb 11 295 (12). 3875-3890
    Wang-Bishop Lihong, Wahbe Mohamed, Shae Daniel, James Jamaal, Hacker Benjamin, Garland Kyle, Christov Plamen, Rafat Marjan, Balko Justin, Wilson John, Potent STING Activation Stimulates Immunogenic Cell Death to Enhance Antitumor Immunity in Neuroblastoma;J Immunother Cancer. 2020 Mar 8 (1). 1-17

    “2019”

    Minko Irina, Christov Plamen, Li Liang, Stone Michael, McCullough Amanda, Lloyd Stephen, Processing of N 5-substituted Formamidopyrimidine DNA Adducts by DNA Glycosylases NEIL1 and NEIL3;DNA Repair. 2019 Jan 73 49-54
    Perry Evan, Mills Jonathan, Zhao Bin, Wang Feng, Sun Qi, Christov Plamen, Tarr James, Rietz Tyson, Olejniczak Edward, Lee Taekyu, Fesik Stephen, Fragment-based Screening of Programmed Death Ligand 1 (PD-L1);Bioorg Med Chem Lett; . 2019 Mar 15 29 (6). 786-790
    Lee Taekyu, Christov Plamen, Shaw Subrata, Tarr James, Zhao Bin, Veerasamy Nagarathanam, Jeon KyuOk, Mills Jonathan, Arnold Alison, Forgaty Stuart, Cook Rebecca, Kim Kwangho, Arteaga Carlos, Olejniczak Edward, Fesik Stephen, Discovery of Potent Myeloid Cell Leukemia-1 (Mcl-1) Inhibitors That Demonstrate in Vivo Activity in Mouse Xenograft Models of Human Cancer;J. Med. Chem.. 2019 Apr 25 62 (8). 3971-3988
    Shae Daniel, Becker Kyle, Christov Plamen, Yun Dong Soo, Lytton-Jean Abigail, SevimliSema, Ascano Manuel, Kelly Mark, JohnsonDouglas, Balco Justin, Wilson John, Endosomolytic Polymersomes Increase the Activity of Cyclic Dinucleotide STING Agonists to Enhance Cancer Immunotherapy;Nature Nanotechnology. 2019 Jan 21 14 (3). 269-278
    Dumas Megan, Chen Geng-Yuan, Kendrick Nicole, Xu George, Larsen Scott, Jana Somnath, Waterson Alex, Bauer A., Hancock William, Sulikowski Gary, Ohi Ryoma, Dual inhibition of Kif15 by oxindole and quinazolinedione chemical probes;Bioorg Med Chem Lett; . 2019 Jan 15 29 (2). 148-154

    “2018”

    Davis Robert , Allweil Alexander, Tian Jianhua, Brash Alan, Sulikowski Gary, Stereocontrolled synthesis of four isomeric linoleate triols of relevance to skin barrier formation and function;Tetrahedron Letter. 2018 Dec 26 59 (52). 4571-4573
    YamanashiH, BoeglinWE, MorisseauC, DavisRW, SulikowskiGA, HammockBD, BrashAR, Catalytic activities of mammalian epoxide hydrolases with and fatty acid epoxides relevant to skin barrier functionJournal of lipid research. 2018 Apr 19 59 (4). 684-695
    AbneyKK, Ramos-HunterSJ, RomaineIM, GoodwinJS, SulikowskiGA, WeaverCD, Selective Activation of N,N’-Diacyl Rhodamine Pro-fluorophores Paired with Releasing Enzyme, Porcine Liver Esterase (PLE)Chemistry (Weinheim an der Bergstrasse, Germany). 2018 Jun 25 24 (36). 8985-8988
    BoerRE, Giménez-BastidaJA, BoutaudO, JanaS, SchneiderC, SulikowskiGA, Total Synthesis and Biological Activity of the Arachidonic Acid Metabolite Hemiketal EOrganic letters. 2018 Dec 6 20 (13). 4020-4022
    DutterBF, EnderA, SulikowskiGA, WeaverCD, Rhodol-based thallium sensors for cellular imaging of potassium channel activityOrganic & biomolecular chemistry. 2018 Aug 8 16 (31). 5575-5579

    “2017”

    Surdel Matthew C, Horvath Dennis J, Lojek Lisa J, Fullen Audra R, Simpson Jocelyn, Dutter Brendan F, Salleng Kenneth J, Ford Jeremy B, Jenkins J Logan, Nagarajan Raju, Teixeira Pedro L, Albertolle Matthew, Georgiev Ivelin S, Jansen E Duco, Sulikowski Gary A, Lacy D Borden, Dailey Harry A, Skaar Eric P, Antibacterial photosensitization through activation of coproporphyrinogen oxidaseProceedings of the National Academy of Sciences of the United States of America. 2017 Dec 8 114 (32). E6652-E6659
    LepeshevaGalina, ChristovPlamen, SulikowskiGary A, KimKwangho, A convergent, scalable and stereoselective synthesis of azole CYP51 inhibitorsTetrahedron letters. 2017 Nov 25 58 (45). 4248-4250

    “2016”

    ChobyJE, Mike LA, Mashruwala AA, Dutter BF, Dunman PM, Sulikowski GA, Boyd JM, Skaar EP, A Small-Molecule Inhibitor of Iron-Sulfur Cluster Assembly Uncovers a Link between Virulence Regulat…Cell chemical biology. 2016 Oct 19
    SurdelMC, Dutter BF, Sulikowski GA, Skaar EP, Bacterial Nitric Oxide Synthase Is Required for the Staphylococcus aureus Response to Heme Stress.ACS infectious diseases. 2016 Aug 12 2 (8). 572-8
    ChongKM, Leelatian N, Deguire SM, Brockman AA, Earl D, Ihrie RA, Irish JM, Bachmann BO, Sulikowski GA, The use of fluorescently-tagged apoptolidins in cellular uptake and response studies.The Journal of antibiotics. 2016 Apr 69 (4). 327-30
    DutterBF, Mike LA, Reid PR, Chong KM, Ramos-Hunter SJ, Skaar EP, Sulikowski GA, Decoupling Activation of Heme Biosynthesis from Anaerobic Toxicity in a Molecule Active in Staphyloc…ACS chemical biology. 2016 May 20 11 (5). 1354-61

    “2015”

    SenterTJ, O'Reilly MC, Chong KM, Sulikowski GA, Lindsley CW, A general, enantioselective synthesis of N-alkyl terminal aziridines and C2-functionalized azetidine…Tetrahedron letters. 2015 Mar 4 56 (10). 1276-1279
    RomaineIM, Sulikowski GA, Studies on a biomimetic oxidative dimerization approach to the hibarimicins.Tetrahedron letters. 2015 Jun 3 56 (23). 3617-3619
    WilliamsCH, Hempel JE, Hao J, Frist AY, Williams MM, Fleming JT, Sulikowski GA, Cooper MK, Chiang C, Hong CC, An in vivo chemical genetic screen identifies phosphodiesterase 4 as a pharmacological target for he…Cell reports. 2015 Apr 7 11 (1). 43-50

    “2014”

    EvansSM, Kim K, Moore CE, Uddin MI, Capozzi ME, Craft JR, Sulikowski GA, Jayagopal A, Molecular probes for imaging of hypoxia in the retina.Bioconjugate chemistry. 2014 Nov 19 25 (11). 2030-7
    RomaineIM, Taylor RW, Saidu SP, Kim K, Sulikowski GA, Zwiebel LJ, Waterson AG, Narrow SAR in odorant sensing Orco receptor agonists.Bioorganic & medicinal chemistry letters. 2014 Jun 15 24 (12). 2613-6

    “2013”

    ThompsonMK, Keithly ME, Harp J, Cook PD, Jagessar KL, Sulikowski GA, Armstrong RN, Structural and chemical aspects of resistance to the antibiotic fosfomycin conferred by FosB from Ba…Biochemistry. 2013 Oct 15 52 (41). 7350-62
    WenW, Wu W, Romaine IM, Kaufmann K, Du Y, Sulikowski GA, Weaver CD, Lindsley CW, Discovery of ‘molecular switches’ within a GIRK activator scaffold that afford selective GIRK inhibi…Bioorganic & medicinal chemistry letters. 2013 Aug 15 23 (16). 4562-6
    KaufmannK, Romaine I, Days E, Pascual C, Malik A, Yang L, Zou B, Du Y, Sliwoski G, Morrison RD, Denton J, Niswender CM, Daniels JS, Sulikowski GA, Xie XS, Lindsley CW, Weaver CD, ML297 (VU0456810), the first potent and selective activator of the GIRK potassium channel, displays …ACS chemical neuroscience. 2013 Sep 18 4 (9). 1278-86

    “2012”

    HargroveTY, Kim K, de Nazaré Correia Soeiro M, da Silva CF, Batista DD, Batista MM, Yazlovitskaya EM, Waterman MR, Sulikowski GA, Lepesheva GI, CYP51 structures and structure-based development of novel, pathogen-specific inhibitory scaffolds.International journal for parasitology, drugs and drug resistance. 2012 Dec 2 178-186
    LiedtkeAJ, Kim K, Stec DF, Sulikowski GA, Marnett LJ, Straightforward protocol for the efficient synthesis of varied N(1)-acylated (aza)indole 2-/3-alkano…Tetrahedron. 2012 Dec 2 68 (48). 10049-10058
    LamersAP, Keithly ME, Kim K, Cook PD, Stec DF, Hines KM, Sulikowski GA, Armstrong RN, Synthesis of bacillithiol and the catalytic selectivity of FosB-type fosfomycin resistance proteins.Organic letters. 2012 Oct 19 14 (20). 5207-9
    TaylorRW, Romaine IM, Liu C, Murthi P, Jones PL, Waterson AG, Sulikowski GA, Zwiebel LJ, Structure-activity relationship of a broad-spectrum insect odorant receptor agonist.ACS chemical biology. 2012 Oct 19 7 (10). 1647-52
    JonesPL, Pask GM, Romaine IM, Taylor RW, Reid PR, Waterson AG, Sulikowski GA, Zwiebel LJ, Allosteric antagonism of insect odorant receptor ion channels.PloS one. 2012 7 (1). e30304
    MelanconBJ, Lamers AP, Bridges TM, Sulikowski GA, Utley TJ, Sheffler DJ, Noetzel MJ, Morrison RD, Daniels JS, Niswender CM, Jones CK, Conn PJ, Lindsley CW, Wood MR, Development of a more highly selective M(1) antagonist from the continued optimization of the MLPCN …Bioorganic & medicinal chemistry letters. 2012 Jan 15 22 (2). 1044-8