Stephen Doster

  • Vanderbilt University

    Clues to lung injury in preterm babies

    Mar. 5, 2020, 1:30 PM by Leigh MacMillan Bronchopulmonary dysplasia (BPD) — a form of chronic lung disease — is a leading complication of preterm birth affecting infants born before 32 weeks gestation. Exposure to high levels of oxygen (hyperoxia) plays a role in BPD pathogenesis, but the precise molecular… Read More

    Mar. 18, 2020

  • Clinical investigation society lauds Vanderbilt scientists

    Clinical investigation society lauds Vanderbilt scientists

    Mar. 12, 2020, 8:45 AM by Bill Snyder Five faculty members of Vanderbilt University School of Medicine are among 80 physician-scientists who will be inducted this year into the American Society for Clinical Investigation (ASCI), an elite honor society of physician-scientists from the upper ranks of academic medicine and industry. Read More

    Mar. 18, 2020

  • Two segments of chromatin are shown. Each is made up of eight yellow balls (laid out in a four-by-two pattern) that represent histones and a colorful thread, representing DNA, that goes around the histones; collectively, these are the nucleosomes . The top chromatin has the nucleosomes more spread out than the bottom chromatin. Gene expression on the top chromatin is represented by a green protein that is shooting out segments of RNA. There is no gene expression on the bottom chromatin: the nucleosomes are tightly packed in a line and the DNA has a smattering of red spots throughout, representing methyl groups.

    ATAC-Me attacks knowledge gap in genetics research

    https://cdn.vanderbilt.edu/vu-web/medschool-wpcontent/sites/64/2020/03/18093522/Hodges.mp4   By Hillary Layden Most human cells contain roughly 6.5 feet of DNA, which must be tightly compacted to fit within the nucleus. Cells compact DNA by wrapping it around proteins called histones, forming a DNA-protein complex called chromatin. “Closed” chromatin is tightly compacted and cannot interact with… Read More

    Mar. 17, 2020

  • Vanderbilt University

    Loss of ‘Jedi’ alters neuron activity

    Mar. 10, 2020, 8:00 AM by Leigh MacMillan The cell bodies of peripheral sensory neurons that respond to and transmit information about stimuli including touch, temperature and pain reside in the dorsal root ganglia (DRG). DRG neuron hyperexcitability is correlated with chronic pain. Bruce Carter’s group… Read More

    Mar. 10, 2020

  • Vanderbilt University

    Breast cancer study may help predict treatment response

    Feb. 27, 2020, 9:53 AM by Bill Snyder Researchers at Vanderbilt University Medical Center are reporting another advance in the understanding and treatment of triple-negative breast cancer, which is particularly aggressive and difficult to treat. Their findings, detailed in the journal Clinical Cancer Research, offer new hope for identifying… Read More

    Feb. 28, 2020

  • Vanderbilt University

    Bordenstein honored by Genetics Society of America

    Feb. 27, 2020, 9:14 AM by Sara Eaton The Genetics Society of America has recognized Seth Bordenstein, PhD, an evolutionary geneticist and microbiologist at Vanderbilt University, for an initiative that brings real-world scientific research into middle school, high school and college biology classes. Seth Bordenstein, PhD Bordenstein, Centennial Professor of… Read More

    Feb. 28, 2020

  • Vanderbilt University

    Protein interactions and brain function

    Forty years since its discovery, much remains to be discovered about an enzyme called CaMKII that plays a key role in shaping learning and memory in the brain. Now Roger Colbran, PhD, graduate student Tyler Perfitt and colleagues report in the Journal… Read More

    Feb. 21, 2020

  • Vanderbilt University

    Post-transplant diabetes may be reversible: study

    Post-transplantation diabetes mellitus (PTDM), a common complication of immunosuppressive drugs that are given to prevent transplant rejection, may be reversible and at least partially preventable, researchers at Vanderbilt University Medical Center report. “We hope these findings can be translated into clinical research as these results suggest ways that diabetes associated… Read More

    Feb. 21, 2020

  • Vanderbilt University

    Transporter mutation alters cell energy

    The cotransporter NKCC1 moves sodium, potassium and chloride ions across the cell membrane and has roles regulating cell volume, epithelial transport and neuronal excitability. Eric Delpire, PhD, and colleagues recently discovered that a patient suffering from multiorgan failure had a mutation in… Read More

    Feb. 21, 2020

  • Vanderbilt University

    Laboratory and administrative personnel at Vanderbilt University Medical Center were honored last week for research excellence during the 16th annual Research Staff Awards luncheon at the Kimpton Aertson Hotel in Nashville. Schaffer, an expert in a wide range of microscopy modalities, is an essential part of the CISR and collaborates… Read More

    Feb. 21, 2020