Stephen Doster

Feb. 6, 2020, 10:10 AM Researchers Timothy Blackwell, MD, left, Erin Plosa, MD, Roy Zent, MD, PhD, and colleagues are studying beta-1 integrin’s role in normal lung function. (photo by Susan Urmy) by Bill Snyder Beta-1 integrin, a critical component of epithelial extracellular matrix receptors, is essential for normal lung… Read More

By Alexandria Oviatt DNA repair pathways such as NER have the integral role of protecting us from potentially damaging mutations. Defects in these mechanisms can lead to diseases such as XP or cancers. (Gernot Krautberger, stock.adobe.com) A recent Nucleic Acids Research paper from the lab of Walter… Read More

By Lorena Infante Lara Stanley Cohen, Nobel laureate, posing next to a portrait of himself. Dr. Stanley Cohen, Vanderbilt University emeritus faculty and Nobel Prize winner, passed away Wednesday morning. He was 97 years old. Born in Brooklyn, New York, in 1922, Cohen was the… Read More

By Amanda N. Johnson “Major depression is one of the most common mental disorders in the U.S. According to the National Institute of Mental Health, approximately 7% (17.3 million) of American adults had at least one major depressive episode in 2017.” (Tadamichi, stock.adobe.com) Existing drug treatments relieve mental illness for… Read More

By Suneethi Sivakumaran C-MYC, a variant of MYC, and MAX bound to DNA. (Molekuul.be, stock.adobe.com) Cancers are complex and diverse in nature, assailing the human body through different mechanisms. Cancer cells outsmart normal cells through myriad mechanisms, including sustained proliferation, insensitivity to growth suppressors, and resistance to cell… Read More

Carlos Lopez (Biochemistry) has received a National Science Foundation Faculty Early Career Development (CAREER) award, the most prestigious NSF award that supports early-career faculty. Lopez’s research attempts to parse out the role of noise and randomness in determining cell fate. Read More

Jan. 29, 2020, 2:23 PM by Bill Snyder MYC is a family of three related proteins that are overexpressed in cancer and which contribute to an estimated 100,000 cancer deaths annually in the United States. Efforts to block MYC directly have failed. Fortunately, these proteins have an Achilles’ heel —… Read More

Jan. 29, 2020, 3:14 PM by Kelsey Herbers Stimulating neural activity between the amygdala and the nucleus accumbens — a brain region associated with pleasure — impairs social function even though mice find the stimulation rewarding, a new study published by Vanderbilt researchers in The Journal of Clinical Investigation… Read More

Jan. 27, 2020, 9:00 AM by Leigh MacMillan Free radicals produced during oxidative stress react with membrane fatty acids to yield highly reactive lipid aldehydes, which can modify proteins and cause cellular or tissue damage. The aldehyde HNE has been shown to modify high-density lipoprotein (HDL, the so-called good cholesterol)… Read More

Jan. 23, 2020, 9:17 AM by Bill Snyder Using part of an antibody isolated at Vanderbilt University Medical Center that “broadly neutralizes” the human dengue virus, biologists at the University of California San Diego and colleagues have disarmed the mosquito that transmits the disabling and potentially deadly tropical infection. Reporting in… Read More