Stephen Doster

A New Approach to RAS Inhibition Image reproduced with permission from T. R. Hodges, et al., (2018) J. Med. Chem., published online September 11, DOI: 10.1021/acs.jmedchem.8b01108. Copyright 2018 American Chemical Society RAS is a small protein that acts as a molecular on/off switch to modulate numerous signaling pathways that… Read More

Promoting Immune-Mediated Therapy in Breast Cancer Image courtesy of Dr. Steven Harmes. Baylor University Medical Center, Dallas Texas. Despite major progress in early diagnosis and treatment, breast cancer (BC) remains the second leading cause of cancer deaths among women in the U.S. A promising new approach to cancer therapy… Read More

Elongating Microvilli in the Intestine Enterocyte showing Brush border and unstirred layer Author: Boumphreyfr Enterocytes, the epithelial cells lining the lumen of the intestine, develop a dense lawn of microvilli (MV) on their apical surface as they differentiate from stem cells in the intestinal crypt. We know that MV… Read More

A Path to Insulin Resistance in Diet-Induced Obesity Increasing evidence indicates that inflammation in adipose tissue (AT) contributes to insulin resistance and other metabolic abnormalities frequently observed in obesity. We know that macrophages in AT play an important role in obesity-associated inflammation and that obese AT can activate proinflammatory… Read More

Seth Smith, PhD, director of the Center for Human Imaging in the Vanderbilt University Institute of Imaging Science (VUIIS), has been appointed the institute’s first associate director. “Seth has served VUIIS for several years as an effective leader of the Center for Human Imaging,” and will continue as associate center… Read More

Schizophrenia and major depressive disorder are both caused by perturbations in dopamine signaling. They belong to a group of common psychiatric disorders that are characterized by deficits in motivation and learning. Treatments targeting specific neurotransmitters have been ineffective. However, evidence is emerging that the immune system is a potential therapeutic… Read More

A team of Vanderbilt University imaging experts won grants in the first round of the National Institutes of Health’s Human BioMolecular Atlas Program (HuBMAP) funding, aimed at developing an open, global framework to map the adult human body at the level of individual cells. Biochemistry professor Richard… Read More

A trans-institutional team of researchers at Vanderbilt University Medical Center and Vanderbilt University has received an $11 million Cancer Moonshot grant to build a single-cell resolution atlas to map out the routes that benign colonic polyps take to progress to colorectal cancer, the third most common cancer among both men… Read More

After serving as the department’s leader for more than 15 years, Samuel A. Santoro, MD, PhD, the Dorothy B. and Theodore R. Austin Professor and Chair of the Department of Pathology, Microbiology and Immunology, will step down from his role as the department’s chair… Read More

The gut is lined by cells containing brush borders, which are composed of arrays of microvillar protrusions that help in nutrient absorption and provide a barrier against pathogens and toxins. Microbes such as E. coli can destroy microvilli with potentially life-threatening results. But how microvilli form has not been well understood. Using… Read More