Lorena Infante Lara
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New cancer target could push new drugs into the clinic
New work by Professor of Cell and Developmental Biology Bill Tansey and colleagues has determined that a new type of inhibitor—a WINi—targets cancer cells in a novel way and suggests exploiting this pathway in future anticancer drug development efforts. Read MoreMay. 14, 2024
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Research Snapshot: Exploring the range of AlphaFold2’s utility within the realm of protein dynamics
Benjamin P. Brown, assistant professor of pharmacology, and colleagues in the departments of molecular physiology and biophysics, pharmacology, and chemistry, have determined that AlphaFold2 can be used to generate approximations of relative conformational preferences of proteins, which will help researchers better understand a protein’s structure and function across a range of conditions and mutational states. Read MoreMay. 9, 2024
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Lau lab publishes authoritative reference article on the hallmarks of precancer
Ken Lau, professor of cell and developmental biology, and colleagues have laid out the principles governing the biology of early, precancerous lesions, which are different from the principles that govern cancers. Their authoritative perspective was published in Cancer Discovery in April 2024. Read MoreMay. 7, 2024
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Hodges lab sheds new light on mechanisms of gene regulatory divergence between species
The labs of Emily Hodges, assistant professor of biochemistry, and Tony Capra, associate professor of epidemiology and biostatistics at the University of California, San Francisco, have devised a method to separate the relative contributions of cis vs. trans regulatory mechanisms to gene regulatory divergence between species. Read MoreApr. 18, 2024
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Nguyen marries basic and translational approaches to ID new brain region responsible for epileptic seizures
Assistant professor of pharmacology Quynh Anh Nguyen spearheaded research that points to a previously unidentified region of the hippocampus as responsible for epileptic seizures. The work could lead to new avenues of treatment to help epilepsy patients control their seizures. Read MoreApr. 17, 2024
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New structures offer insight into how a bacterial motor powers bacterial chemotaxis, a key-infectious-process
An international collaboration led by Professor of Pharmacology Tina Iverson was spotlighted by the popular YouTube channel Smarter Every Day. Iverson's work identified how bacteria move in response to their environment, a process essential for infection by pathogens. Read MoreApr. 17, 2024
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Hinton lab maps structure of mitochondria at different life stages
Antentor Hinton Jr. spearheaded a collaboration with labs from across Vanderbilt University, the U.S., and Brazil to create 3D maps of mitochondria inside brown adipose tissue, which may help researchers identify potential therapies to treat metabolic ailments. Read MoreApr. 4, 2024
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Guengerich proposes paradigm shift in enzyme biochemistry
The lab of Professor of Biochemistry Fred Guengerich has proposed a paradigm shift in the understanding of a critical chemical reaction involved in sterol biosynthesis. Read MoreFeb. 22, 2024
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Destination Biochemistry welcomes Baris and Pollenz—and new applicants
Baris and Pollenz have been selected as the Danzo and Cohen Postdoctoral Scholars, respectively. Destination Biochemistry applications for the next cohort are due Thursday, Feb. 15. Read MoreFeb. 2, 2024
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Study uses new tools, machine learning to investigate major cause of blindness in older adults
An international collaboration led by Vanderbilt researchers has identified a key component in lesions associated with age-related macular degeneration (AMD), a leading cause of blindness in older adults. Read MoreDec. 20, 2023