Research, News & Discoveries

Sanjay Mishra, Shu-Yu Wu, Ph.D., and colleagues led by Hassane Mchaourab, Ph.D., recently reported in the Journal of Biological Chemistry the use of CRISPR editing in zebrafish to specifically delete alpha-B crystallin genes, which play roles in maintaining lens transparency in the eye and heart muscle integrity. It was the first time both… Read More

A team of Vanderbilt investigators examined the entire training pathway of potential faculty candidates to identify points of greatest loss of URM trainees. They reported recently in PLOS ONE two key points of loss: during undergraduate education and in transition from postdoctoral fellowship to tenure-track faculty. The authors suggest focusing additional interventions on… Read More

Vanderbilt University Medical Center (VUMC) on Monday held its first Directorship Celebration to honor and support eight of its leaders in clinical care, research, education and administration. One of the honorees is Jennifer Pietenpol, Director, Vanderbilt-Ingram Cancer Center and Executive Vice President for Research. “These directorships are critical to our entire institution, as… Read More

Clostridium difficile (C. difficile) infection is the leading cause of hospital-acquired diarrhea, causing nearly a half million infections in the United States each year. Recurrence after treatment with antibiotics is common and new therapies are needed. Now Heather Kroh, PhD, Ramyavardhanee Chandrasekaran, PhD, Ben Spiller, PhD, Borden Lacy, PhD, and colleagues show that the antibody,… Read More

Researchers at Vanderbilt University have discovered how insulin crosses the capillary endothelium to exit blood vessels and stimulate skeletal muscle cells — a major finding that may lead to new ways to reverse insulin resistance, a hallmark of type 2 diabetes. Their discovery, published earlier this month by the Journal of Clinical Investigation, was… Read More

Researchers at Vanderbilt University Medical Center (VUMC) have demonstrated for the first time that it is possible to starve a tumor and stop its growth with a newly discovered small compound that blocks uptake of the vital nutrient glutamine. Their findings, reported in this week in Nature Medicine, lay the groundwork for… Read More

New Insights into Autism Spectrum Disorder Autism Spectrum Disorder (ASD) comprises a group of developmental disorders characterized by a wide range of symptoms, typically including impaired social interactions and excessive repetitive behaviors. Increasing evidence suggests that the pathophysiology of ASD involves an imbalance between two neuronal pathways, which are… Read More

Multiplexing Natural Products Discovery An organism’s metabolome is the total of all the small molecules that it produces. Efforts to identify bioactive natural products in the metabolomes of microbes, plants, and other organisms are often thwarted by metabolome complexity and the heterogeneous nature of the cell populations to which… Read More

Bingshan Li, associate professor of molecular physiology and biophysics, and David Weaver, associate professor of pharmacology, have been named to the 2018 class of Chancellor Faculty Fellows. The class comprises highly accomplished, recently tenured faculty from all corners of campus. The faculty members will hold the title of Chancellor Faculty Fellow and will be supported by… Read More

Claus Schneider, PhD, and colleagues have now discovered that curcumin is a “pro-drug” that is converted into reactive metabolites with anti-inflammatory activities. The metabolites of curcumin, produced by oxidation reactions, covalently bind to and inhibit proteins in the inflammatory NF-kappa-B signaling pathway. The researchers found that curcumin undergoes oxidation reactions readily in… Read More