Research, News & Discoveries

Susan R. Wente has served dual roles as biomedical scientist and interim chancellor and provost This story will run in full in the inaugural, Summer 2020 issue of Vestigo, the magazine from the School of Medicine Basic Sciences. When the first reports of an unusual new respiratory disease made news in January,… Read More

By Heather Caslin Approximately 30 million Americans have type 2 diabetes. The majority are over 45 years old. © Vitalii Vodolazskyi, stock.adobe.com Within the pancreas, β-cells produce insulin that delivers energy to tissues through glucose. People with type 2 diabetes have smaller, less functional β-cells; however, the mechanisms that drive… Read More

by Marissa Shapiro Jun. 24, 2020, 11:57 AM By applying unsupervised and automated machine learning techniques to the analysis of millions of cancer cells,Rebecca Ihrie and Jonathan Irish, both associate professors of cell and developmental biology, have identified new cancer cell types… Read More

Jun. 22, 2020, 8:00 AM by Leigh MacMillan Lennox-Gastaut syndrome is a severe early-onset seizure disorder that includes cognitive and behavioral abnormalities. Its pathophysiology is largely unknown.  Recent whole-exome sequencing in patients with Lennox-Gastaut syndrome identified a spontaneous mutation in the gene encoding a GABA-A receptor subunit implicated in other childhood epilepsies. … Read More

By Dana Meeks Ten outstanding faculty members from across the university have been selected for the 2020 cohort of Chancellor Faculty Fellows. This group is composed of highly accomplished, recently tenured faculty from a wide variety of disciplines and areas of expertise. “Investing in this remarkable group of… Read More

Jun. 18, 2020, 11:00 AM by Leigh MacMillan Cells missing the protein HMCES are hypersensitive to DNA-damaging agents that cause a common type of DNA lesion — an “abasic” site. But the agents also generate other types of lesions associated with mutations and cell lethality, making it unclear whether HMCES… Read More

Jun. 18, 2020, 10:30 AM by Bill Snyder Single-cell RNA sequencing is a powerful tool for identifying transcriptomic variations and developmental trajectories in cell types that determine the course of diseases like cancer, with the goal of eventually improving diagnosis and treatment. … Read More

Jun. 12, 2020, 10:00 AM   by Leigh MacMillan Vanderbilt University Medical Center investigators have used high-throughput robotic technology to rapidly study and classify variations in a gene linked to heart rhythm disorders and cardiac conditions. The findings, reported in the American Journal of Human Genetics,… Read More

by Ryan Underwood Jun. 16, 2020, 4:23 PM Vanderbilt University’s Warren Center for Neuroscience Drug Discovery has entered into an exclusive worldwide licensing and collaboration agreement with San Diego-based ACADIA Pharmaceuticals Inc., which will seek to develop and commercialize treatments for central… Read More

Dear Colleagues, I am delighted to announce that David Cortez, PhD, has been named Associate Director for Basic Science Research at Vanderbilt-Ingram Cancer Center.  Dave joined Vanderbilt University in 2002 and is the Richard Armstrong Professor of Biochemistry. He is an expert in the field of DNA damage response… Read More