Macara abstract painting makes cover of Developmental Cell
Ian Macara’s abstract painting representing the response of skin to DNA damage made the December 7 cover of Developmental Cell (Volume 55, Issue 5). The white area on the right of the image represents a hair follicle, the red represents activated hyper-proliferating epidermal cells, the black is DNA crosslinking in response to cisplatin treatment, and the spiky lines below represent activated fibroblasts releasing IL-1β.
To learn more about the effect of DNA damage on wild-type epithelial tissue, see “DNA Damage Promotes Epithelial Hyperplasia and Fate Mis-specification via Fibroblast Inflammasome Activation,” by Lindsey Seldin and Ian Macara, pp. 558–573.