The Vanderbilt Genome Editing Resource (VGER), formerly the Transgenic Mouse/ES Cell Shared Resource, has been a vital part of genetic research at Vanderbilt University for over 30 years. VGER specializes in creating genetically modified mouse models, offering advanced services such as CRISPR/Cas9 genome editing, cryopreservation, and rederivation. Since 2013, it has produced over 190 genome-edited alleles utilizing CRISPR/Cas9. VGER has also cryopreserved more than 1,000 unique mouse strains—82 of which are available through the Vanderbilt Cryopreserved Mouse Repository. Supporting over 380 investigators, VGER has generated more than 3,500 unique mouse strains that have significantly advanced biomedical research. The resource operates under the guidance of the Vanderbilt Center for Stem Cell Biology and institutional oversight committees to ensure scientific excellence and accessibility. In addition to technical services, VGER offers expert consultation and collaborative support for developing novel mouse and pluripotent stem cell models. Its mission is to empower scientific discovery by enabling the creation, preservation, and sharing of genetically engineered research models.