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Mission The mission of the VU Biomolecular Multimodal Imaging Center (BIOMIC) isto build a platform of integrated technologies for imaging and molecular analysis that enables the construction of comprehensive 3-dimensional (3-D) molecular atlases of human tissues. The technologies that we are bringing together in BIOMIC have been specifically selected to… Read More

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Dec. 6, 2018, 10:49 AM by Bill Snyder Pulmonary-renal syndrome (PRS) refers to a group of rare but potentially fatal conditions that nearly always are caused by a misguided attack by the body’s immune system on the lungs and kidneys. Coughing up blood and blood in the urine are telltale… Read More

Dec. 6, 2018, 10:24 AM by Bill Snyder Researchers at Vanderbilt University Medical Center and colleagues have isolated a human monoclonal antibody that can “neutralize” the West Nile virus and potentially prevent a leading cause of viral encephalitis (brain inflammation) in the United States. Their findings, reported last week… Read More

Erin Calipari, Assistant Professor of Pharmacology, Vanderbilt Center for Addiction Reseach, recently won a Mallinckrodt Jr Foundation award providing funding for 3 years at $60,000 per year. See more about her addiction research here. Read More

The rapidly growing field of systems biology attempts to develop mathematical models that both describe and predict complex cellular behavior. Our increasing sophistication in computational statistical approaches has rendered almost routine the process of developing models that “fit” a dataset extremely well. However, most such models fail to predict… Read More

Multidrug Resistance Transporter Dynamics Multidrug resistance promotes cell survival in the presence of toxic compounds such as many antibacterial or cancer chemotherapeutic agents. Often, multidrug resistance results from expression of transport proteins that eject the toxicant from the cell in exchange for Na+ or H+ ions. Researchers believe that… Read More

Addiction-Related Transcription Changes in the Brain Mounting evidence indicates that drug addiction leads to long-term adaptations within the brain’s reward circuitry. One outcome of this is that exposure to the drug or drug-associated cues can trigger a relapse of addiction even after a long period of abstinence. Research has… Read More

Mitochondria are cellular organelles with their own DNA. Their role in power generation makes them susceptible to oxidative damage, including the formation of DNA-damaging chemical complexes called adducts. While one such adduct, M1dG, is normally excised by cells from the genomic DNA, mitochondria apparently lack this repair mechanism. This month in… Read More

Focus on Mitochondrial DNA Damage DNA damage occurs constantly as a result of physical and chemical insults. Such insults include direct oxidation of the DNA or attack by reactive species generated by the oxidation of lipids. These reactions produce many forms of damage, among them an exocyclic adduct of… Read More