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Department of Biochemistry

Christian Meyer

Quaranta Lab

Cancer heterogeneity is a putative mechanism of resistance in a broad array of cancer pathologies.  The probabilities of macro-evolutionary changes which initiate resistance are low, yet resistance remains nearly ubiquitous.  We have observed spontaneous heterogeneity in triple negative breast cancer cells on short time-scales in surface markers stratifying differentiation of the normal breast.  We hypothesize these micro-evolutionary dynamics play a buffer role in initial response to therapy.  We are using an information theory formalism to quantify the micro evolutionary dynamics in triple negative breast cancer.

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