Author
Genetic interactions between hepatocyte nuclear factor-6 and notch signaling
Sep. 20, 2011—Genetic interactions between hepatocyte nuclear factor-6 and notch signaling regulate mouse intrahepatic bile duct development in vivo Charles Vanderpool1, Erin E. Sparks2, Kari A. Huppert2, Maureen Gannon3, Anna L. Means4, Stacey S. Huppert2,*,† DOI: 10.1002/hep.24631 Abstract Notch signaling and hepatocyte nuclear factor-6 (HNF-6) are two genetic factors known to affect lineage commitment in the bipotential...
Mechanism of plus-end targeting by the kinesin-8 Kif18A
Sep. 1, 2011—A Tethering Mechanism Controls the Processivity and Kinetochore-Microtubule Plus-End Enrichment of the Kinesin-8 Kif18A Jason Stumpff2, 4, Yaqing Du1, 4, Chauca A. English1, Zoltan Maliga3, Michael Wagenbach2, Charles L. Asbury2, Linda Wordeman2, 4, , and Ryoma Ohi1, 4, 1 Department of Cell and Developmental Biology, Vanderbilt University Medical Center, Nashville, TN, 37232 2 Department of Physiology and...
cell reprogramming by forced Pdx1 expression
Sep. 1, 2011—Context-specific α-to-β-cell reprogramming by forced Pdx1 expression Yu-Ping Yang1,Fabrizio Thorel2,Daniel F. Boyer1,Pedro L. Herrera2 and Christopher V.E. Wright1,3 1Vanderbilt University Program in Developmental Biology, Department of Cell and Developmental Biology, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA; 2Department of Cell Physiology and Metabolism, University of Geneva Faculty of Medicine, CH-1211 Geneva 4, Switzerland Abstract...
Neural crest stem cell multipotency requires Foxd3
Apr. 19, 2011—eural crest stem cell multipotency requires Foxd3 to maintain neural potential and repress mesenchymal fates Nathan A. Mundell1,2,3 and Patricia A. Labosky1,2,3,4,* 1 Center for Stem Cell Biology, Vanderbilt University School of Medicine, Nashville, TN 37232-0494, USA. 2 Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, TN 37232-0494, USA. 3 Program in Developmental Biology,...
Coupling chromosome segregation and cytokinesis involves signaling scaffold ubiquitination
Feb. 25, 2011—EMBO J. 2011 Jan 19;30(2):341-54. Epub 2010 Dec 3. Dma1 ubiquitinates the SIN scaffold, Sid4, to impede the mitotic localization of Plo1 kinase. Johnson AE, Gould KL. Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN, USA. Abstract Proper cell division requires strict coordination between mitotic exit and cytokinesis. In the...
Casagrande’s contributions to anatomical science honored
Feb. 17, 2011—Casagrande’s contributions to anatomical science honored BY: BILL SNYDER 2/10/2011 – Vivien Casagrande, Ph.D., professor of Cell & Developmental Biology at Vanderbilt University, has been named a fellow of the American Association of Anatomists. Vivien Casagrande, Ph.D. The honor recognizes “excellence in science and in … overall contributions to the anatomical sciences.” Casagrande, who also is...
The neural crest regulates beta cell proliferation and maturation
Feb. 17, 2011—Influence and timing of arrival of murine neural crest on pancreatic beta cell development and maturation Received 30 June 2010; revised 27 October 2010; accepted 5 November 2010. Available online 14 November 2010. Abstract Interactions between cells from the ectoderm and mesoderm influence development of the endodermally-derived pancreas. While much is known about how mesoderm...
Defects in hepatic Notch signaling
Feb. 11, 2011—Defects in hepatic Notch signaling result in disruption of the communicating intrahepatic bile duct network in mice. Sparks EE, Perrien DS, Huppert KA, Peterson TE, Huppert SS. Department of Cell and Developmental Biology and Center for Stem Cell Biology, Vanderbilt University Medical Center, Nashville, TN 37232, USA. Abstract Abnormal Notch signaling in humans results in...
Foxd3 and Pax3 are important early regulators
Jan. 12, 2011—Cardiac neural crest development requires genetic interaction between the transcription factors Foxd3 and Pax3 Abstract The transcription factors Foxd3 and Pax3 are important early regulators of neural crest (NC) progenitor cell properties. Homozygous mutations of Pax3 or a homozygous NC-specific deletion of Foxd3 cause marked defects in most NC derivatives, but neither loss of both...
Labosky named to direct Office of Postdoctoral Affairs
Jan. 12, 2011—Labosky named to direct Office of Postdoctoral Affairs BY: BILL SNYDER 1/06/2011 – Patricia Labosky, Ph.D., associate professor of Cell & Developmental Biology and of Pharmacology, has been named director of the Office of Postdoctoral Affairs at Vanderbilt University Medical Center. Patricia Labosky, Ph.D. Labosky succeeds Ann Richmond, Ph.D., professor and vice chair of Cancer Biology,...