Chin Chiang, Ph.D.
Professor of Cell and Developmental Biology
- : email@example.com
- : (615) 343-4922
4110 Medical Research Building 3
4114 Medical Research Building 3
Our laboratory is interested in how defined numbers of functionally and neurochemically different neurons are established and later incorporated into a functional cerebellar circuit, and how defined perturbations of this circuitry affects the ability of animals to integrate and process sensory information.
Our laboratory is interested in the function of signaling mechanisms in brain development and cancers. We study how secretion and transport of the Sonic hedgehog protein (Shh) are regulated. We also study the role of Shh signal in the genesis of the functional adult brain, and how Shh signal aberration drives formation and maintenance of cancers. We use cutting edge techniques and multidisciplinary approaches that include the utilization of targeted genetic manipulation, live cell imaging, gene expression profiling and orthotopic grafting of tumor cells, combined with state-of-the-art localized stereotaxic injection system for in vivo gene delivery and manipulation.
Postdoctoral Positions Available
Contact Chin Chiang for more details.
The Purkinje neuron acts as a central regulator of spatially and functionally distinct cerebellar precursors. Developmental cell. 2013 Nov 11;27(3). 278-92.PMID: 24229643 [PubMed].PMCID: PMC3860749.NIHMSID: NIHMS532511., He W, Hao C, Ketova T, Pan FC, , Litingtung Y, .