Kathleen L. Gould, Ph.D.
Louise B. McGavock Chair
Professor of Cell and Developmental Biology
Sr. Associate Dean for Biomedical Research, Education, and Career Development
AAAS Fellow - 2011
Mechanism and regulation of cell division
The Gould Lab conducts pioneering research to better understand the molecular basis of cell division (cytokinesis), a highly conserved process central to development and tissue maintenance. We use the genetically tractable fission yeast Schizosaccharomyces pombe as a primary model organism for our studies, with the goal of obtaining a comprehensive mechanistic understanding of cell division in eukaryotic organism. Over the years, we have identified and characterized many evolutionarily conserved constituents of the cytokinetic machinery and discovered how post-translational modifications of this machinery ensure the exquisite spatial and temporal control of cell division. The laboratory has always adopted a multi-disciplinary approach and has acquired complementary expertise in genetic, biochemical, structural, LC-MS/MS-based proteomics, and live cell imaging approaches, making significant contributions to the understanding of cell division, and establishing paradigms of regulation extendable to other biological processes.
Postdoctoral Positions Available
Yes, please see lab website.
McDonald NA, Lind AL, Smith SE, Li R, Nanoscale architecture of the Schizosaccharomyces pombe contractile ring. ELife. 2017 Sep 15;6. e28865.PMID: 28914606 [PubMed].PMCID: PMC5779233 ..
Snider CE, Willet AH, Chen JS, Arpağ G, Zanic M, Phosphoinositide-mediated ring anchoring resists perpendicular forces to promote medial cytokinesis. The Journal of Cell Biology. 2017 Aug 7;216(10). 3041-3050.PMID: 28784611 [PubMed].PMCID: PMC5626552..
McDonald NA, Takizawa Y, Feoktistova A, Xu P, Ohi MD, Vander Kooi CW, The Tubulation Activity of a Fission Yeast F-BAR Protein Is Dispensable for Its Function in Cytokinesis. Cell Reports. 2016 Jan 26;14(3). 534-46.PMID: 26776521 [PubMed].PMCID: PMC4731314..
McDonald NA. Vander Kooi CW, Ohi MD, Oligomerization but Not Membrane Bending Underlies the Function of Certain F-BAR Proteins in Cell Motility and Cytokinesis Developmental Cell. 2015 Dec 21;35(6). 725-736.PMID: 26702831 [PubMed].PMCID: PMC4691284..
Bohnert KA, Grzegorzewska AP, Willet AH, Vander Kooi CW, Kovar DR, SIN-dependent phosphoinhibition of formin multimerization controls fission yeast cytokinesis. Genes & Development. 2013 Oct 1;27(19). 2164-77.PMID: 24115772 [PubMed].PMCID: PMC3850099..