Krishna C. Mudumbi
Research Assistant Professor, Cell and Developmental Biology
- : krishna.mudumbi@vanderbilt.edu
- :
3160A MRB III
465 21st Avenue South
Nashville, Tennessee - 37232
The Mudumbi lab is fundamentally interested in the mechanistic underpinnings of signal transduction by cell surface transmembrane receptors.
Lab Website
To understand the mechanisms of receptor mediated signaling, the Mudumbi lab combines cutting-edge live cell imaging techniques – single-particle tracking (SPT), single-molecule Förster resonance energy transfer (smFRET), super-resolution microscopy, and single-cell FRET to name a few – with a number of other biochemical and molecular biology approaches (phosphoproteomics, signaling assays, etc). The research in the Mudumbi lab has two main focuses: 1) receptor activation kinetics and 2) downstream signaling kinetics. By understanding the kinetics of signal transduction from the level of both receptor signaling and downstream events, we hope to build a ‘kinetic landscape’ to understand how receptors achieve distinct signaling responses through the same receptor. This will allow us to target these kinetics with therapeutics and modulate or ‘fine-tune’ them for specific cellular outcomes.