Apical polarization and lumenogenesis: The apicosome sheds new light.
Romero-Morales AI , Ortolano NA , Gama V , . The Journal of cell biology. 2017 12 4; 216(12). 3891-3893
- PMID: 29138252 [PubMed].
- PMCID: PMC5716292.
Establishment of apico-basal polarity is critical for the lumenal epiblast-like morphogenesis of human pluripotent stem cells (hPSCs). In this issue, Taniguchi et al. (2017. https://doi.org/10.1083.jcb201704085) describe a structure called the apicosome, generated in single hPSCs, that allows them to self-organize and form the lumenal epiblast-like stage.
Tags: Publications, Student Publications