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ErbB3 drives mammary epithelial survival and differentiation during pregnancy and lactation.


Williams MM , Vaught DB , Joly MM , Hicks DJ , Sanchez V , Owens P , Rahman B , Elion DL , Balko JM , Cook RS , . Breast cancer research : BCR. 2017 9 8; 19(1). 105


During pregnancy, as the mammary gland prepares for synthesis and delivery of milk to newborns, a luminal mammary epithelial cell (MEC) subpopulation proliferates rapidly in response to systemic hormonal cues that activate STAT5A. While the receptor tyrosine kinase ErbB4 is required for STAT5A activation in MECs during pregnancy, it is unclear how ErbB3, a heterodimeric partner of ErbB4 and activator of phosphatidyl inositol-3 kinase (PI3K) signaling, contributes to lactogenic expansion of the mammary gland.