T cells expressing checkpoint receptor TIGIT are enriched in follicular lymphoma tumors and characterized by reversible suppression of T-cell receptor signaling.
AUTHORS
Josefsson
SE ,
Huse
K ,
Kolstad
A ,
Beiske
K ,
Pende
D ,
Steen
CB ,
Inderberg
EM ,
Lingjærde
OC ,
Østenstad
B ,
Smeland
EB ,
Levy
R ,
Irish
JM ,
Myklebust
JH ,
. Clinical cancer research : an official journal of the American Association for Cancer Research. 2017 12 7; ().
- PMID: 29217528 [PubMed].
ABSTRACT
T cells infiltrating follicular lymphoma (FL) tumors are considered dysfunctional, yet the optimal target for immune checkpoint blockade is unknown. Characterizing co-inhibitory receptor expression patterns and signaling responses in FL T-cell subsets might reveal new therapeutic targets.
Tags: Publications