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The Elegance of Sonic Hedgehog: Emerging Novel Functions for a Classic Morphogen


Garcia ADR , Han YG , Triplett JW , Farmer WT , Harwell CC , Ihrie RA , . The Journal of neuroscience : the official journal of the Society for Neuroscience. 2018 10 31; 38(44). 9338-9345


Sonic Hedgehog (SHH) signaling has been most widely known for its role in specifying region and cell-type identity during embryonic morphogenesis. This mini-review accompanies a 2018 SFN mini-symposium that addresses an emerging body of research focused on understanding the diverse roles for Shh signaling in a wide range of contexts in neurodevelopment and, more recently, in the mature CNS. Such research shows that Shh affects the function of brain circuits, including the production and maintenance of diverse cell types and the establishment of wiring specificity. Here, we review these novel and unexpected functions and the unanswered questions regarding the role of SHH and its signaling pathway members in these cases.